On the evolution of cellular senescence.
On the evolution of cellular senescence.
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关于细胞衰老的演变。
DOI：
10.1111/acel.13270
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发表时间：
2020-12
期刊：
影响因子：
7.8
通讯作者：
Kirkwood TBL
中科院分区：
文献类型：
--
作者：
Kowald A;Passos JF;Kirkwood TBL
衰老细胞与衰老有因果关系的观点得到了强有力的支持，这些发现表明，去除这些细胞可以减轻许多与年龄相关的疾病，并延长小鼠的寿命。在努力将这些发现用于治疗的同时，为了更好地理解我们可能寻求改变的生物学，重要的是要问细胞衰老出现背后的进化力量是什么。细胞衰老通常被认为是一种抗癌机制，因为它限制了细胞的分裂潜力。然而，许多研究表明，衰老细胞通常也具有致癌特性。这很难与简单的抗癌机制相一致。此外，其他研究表明，细胞衰老参与伤口愈合和组织修复。在这里，我们将这些发现和想法结合在一起，讨论这些功能可能是细胞衰老进化的主要原因的可能性。此外，我们还讨论了衰老细胞可能随着年龄的增长而积累的观点，因为免疫系统必须在假阴性（忽略一些衰老细胞）和假阳性（破坏健康的身体细胞）之间取得平衡。细胞衰老通常被认为是一种抗癌机制，尽管许多研究表明衰老细胞通常也具有致癌特性。在这里，我们讨论了实际上伤口愈合、组织修复和发育可能是细胞衰老进化的主要原因的可能性。我们还认为，衰老细胞可能随着年龄的增长而积累，因为免疫系统必须在假阴性和假阳性之间取得平衡。
The idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related diseases and extends the life span of mice. While efforts proceed to make therapeutic use of such discoveries, it is important to ask what evolutionary forces might have been behind the emergence of cellular senescence, in order better to understand the biology that we might seek to alter. Cellular senescence is often regarded as an anti‐cancer mechanism, since it limits the division potential of cells. However, many studies have shown that senescent cells often also have carcinogenic properties. This is difficult to reconcile with the simple idea of an anti‐cancer mechanism. Furthermore, other studies have shown that cellular senescence is involved in wound healing and tissue repair. Here, we bring these findings and ideas together and discuss the possibility that these functions might be the main reason for the evolution of cellular senescence. Furthermore, we discuss the idea that senescent cells might accumulate with age because the immune system had to strike a balance between false negatives (overlooking some senescent cells) and false positives (destroying healthy body cells). Cellular senescence is often regarded as an anti‐cancer mechanism although many studies have shown that senescent cells often also have carcinogenic properties. Here, we discuss the possibility that actually wound healing, tissue repair, and development might be the main reason for the evolution of cellular senescence. We also suggest that senescent cells might accumulate with age because the immune system has to strike a balance between false negatives and false positives.
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影响因子：
64.5
作者：
Burd CE;Sorrentino JA;Clark KS;Darr DB;Krishnamurthy J;Deal AM;Bardeesy N;Castrillon DH;Beach DH;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
13.1
作者：
Burton, Dominick G. A.;Stolzing, Alexandra
通讯作者：
Stolzing, Alexandra