Quest for the Vulnerable Atheroma: Carotid Stenosis and Diametric Strain--A Feasibility Study.
Quest for the Vulnerable Atheroma: Carotid Stenosis and Diametric Strain--A Feasibility Study.
复制标题
DOI：
10.1016/j.ultrasmedbio.2015.11.002
复制
发表时间：
2016-03
影响因子：
2.9
通讯作者：
Beach KW
中科院分区：
文献类型：
--
作者：
Xu C;Yuan C;Stutzman E;Canton G;Comess KA;Beach KW
伯努利效应可能导致脆弱的颈动脉粥样硬化爆发，从而导致中风。我们使用超声组织多普勒方法测量了心电图（ECG）记录的QRS狭窄内血流速度和颈动脉壁粥样硬化应变动力学，提供的位移和时间分辨率为0.1 μm和3.7 ms。在22条动脉中，1条动脉的收缩期峰值流速（PSV）>280 cm/s，4例PSV在165 - 280 cm/s之间，17例PSV <165 cm/s。PSV <65 cm/s的8支动脉和PSV在65 ~ 165 cm/s的9支动脉中有4支收缩期内径扩张正常（0%和7%），相应的收缩期管壁变薄。其余10条动脉收缩期应变动力学异常，2条动脉直径缩小（>-0.05 mm），2条动脉壁极度扩张（>0.1 mm），2条动脉壁极度变薄（>-0.1 mm），4条动脉合并。收缩期直径减小和/或收缩期动脉壁极度增厚可能提示动脉粥样硬化即将破裂。
The Bernoulli effect may result in eruption of a vulnerable carotid atheroma, causing a stroke. We measured electrocardiography (ECG)-registered QRS intra-stenotic blood velocity and atheroma strain dynamics in carotid artery walls using ultrasonic tissue Doppler methods, providing displacement and time resolutions of 0.1 μm and 3.7 ms. Of 22 arteries, 1 had a peak systolic velocity (PSV) >280 cm/s, 4 had PSVs between 165 and 280 cm/s and 17 had PSVs <165 cm/s. Eight arteries with PSVs <65 cm/s and 4 of 9 with PSVs between 65 and 165 cm/s had normal systolic diametric expansion (0% and 7%) and corresponding systolic wall thinning. The remaining 10 arteries had abnormal systolic strain dynamics, 2 with diametric reduction (>−0.05 mm), 2 with extreme wall expansion (>0.1 mm), 2 with extreme wall thinning (>−0.1 mm) and 4 with combinations. Decreases in systolic diameter and/or extreme systolic arterial wall thickening may indicate imminent atheroma rupture.