Surface Plasmon Properties of Hollow Auag Alloyed Triangular Nanoboxes and its Applications in Sers Imaging and Potential Drug Delivery
Surface Plasmon Properties of Hollow Auag Alloyed Triangular Nanoboxes and its Applications in Sers Imaging and Potential Drug Delivery
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DOI：
10.2528/pier12041908
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发表时间：
2012
影响因子：
6.7
通讯作者：
Xinwei Liu;Jiao Lin;T. Jiang;Zhenfeng Zhu;Qiuqiang Zhan;J. Qian;Sailing He
中科院分区：
文献类型：
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作者：
Xinwei Liu;Jiao Lin;T. Jiang;Zhenfeng Zhu;Qiuqiang Zhan;J. Qian;Sailing He
我们成功地合成了中空的金银合金三角形纳米盒（TNB），其局域表面等离子体共振（LSPR）光谱的位置从可见光到近红外区域。然后，我们研究了AuAg合金TNB的表面等离子体特性，并探讨了它们在表面增强拉曼散射（Sers）成像中的应用。我们还研究了激光诱导的近场消融TNB，这有可能用于癌症治疗的药物输送。首次采用时域有限差分法（FDTD）计算了AuAg合金TNB的LSPR光激发产生的电磁场。通过三种基于TNB的Sers标签的活体成像验证了计算结果。此外，TNB独特的中空结构可以促进抗癌药物的直接包封，而没有任何表面涂层。研究了飞秒激光近场烧蚀实验，作为一种可能的方法来释放封装在中空结构内的药物。这些研究表明，纳米结构很容易分解，并有希望作为一个纳米器件模型的控制药物输送。接收日期2012年4月19日，接受日期2012年5月15日，预定日期2012年5月15日 * 通讯作者：Sailing He（sailing@kth.se）.
We successfully synthesized hollow AuAg alloyed triangular nanoboxes (TNBs) with localized surface plasmon resonances (LSPR) spectra position from visible to NIR region. We then study the surface plasmon properties of AuAg alloyed TNBs and explore their application in surface enhanced Raman scattering (SERS) imaging. We also investigated the laser induced near-field ablation of TNBs, which have the potentials of drug delivery for cancer treatment. Finite Difference Time Domain (FDTD) method is used to calculate electromagnetic fields induced by optical excitation of LSPR of AuAg alloyed TNBs for the first time. The calculated results are proved through in-vivo SERS imaging by three types of SERS tags based on TNBs. Furthermore, the unique hollow structure of TNBs may facilitate direct encapsulation of anticancer drugs, without any surface coatings. The femtosecond laser near-field ablation experiment is studied as one possible method to release the drug encapsulated inside the hollow structure. These studies show that the nanostructures are easy to break down and promising as a nanodevice model for controlled drug delivery. Received 19 April 2012, Accepted 15 May 2012, Scheduled 15 May 2012 * Corresponding author: Sailing He (sailing@kth.se).