The Role of Exosomal VP40 in Ebola Virus Disease.
The Role of Exosomal VP40 in Ebola Virus Disease.
复制标题
外泌体 VP40 在埃博拉病毒疾病中的作用。
DOI：
10.1089/dna.2017.3639
复制
发表时间：
2017
影响因子：
3.1
通讯作者：
Kashanchi,Fatah
中科院分区：
文献类型：
--
作者：
Pleet,MichelleL;DeMarino,Catherine;Lepene,Benjamin;Aman,MJavad;Kashanchi,Fatah
Ebola virus (EBOV) can cause a devastating hemorrhagic disease, leading to death in a short period of time. After infection, the resulting EBOV disease results in high levels of circulating cytokines, endothelial dysfunction, coagulopathy, and bystander lymphocyte apoptosis in humans and nonhuman primates. The VP40 matrix protein of EBOV is essential for viral assembly and budding from the host cell. Recent data have shown that VP40 exists in the extracellular environment, including in exosomes, and exosomal VP40 can impact the viability of recipient immune cells, including myeloid and T cells, through the regulation of the RNAi and endosomal sorting complexes required for transport pathways. In this study, we discuss the latest findings of the impact of exosomal VP40 on immune cellsin vitroand its potential implications for pathogenesisin vivo.
