Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.
Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.
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DOI：
10.1093/abbs/gmt001
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发表时间：
2013-03
影响因子：
3.7
通讯作者：
Qiaoqiao Wang;Ji-Yu Li;Xinmiao Yang;Hefen Sun;Shuiping Gao;Hua Zhu;Jiong Wu;W. Jin
中科院分区：
文献类型：
--
作者：
Qiaoqiao Wang;Ji-Yu Li;Xinmiao Yang;Hefen Sun;Shuiping Gao;Hua Zhu;Jiong Wu;W. Jin
BRCA 1与乳腺癌的发病机制密切相关。BRCA 1启动子的活性受转录因子调控。转录因子Nrf 2（Nuclear factor-erythroid-2 p45-related factor 2）是一种有效的转录激活因子，在许多细胞保护基因的诱导表达中起核心作用。在本报告中，我们发现过表达Nrf 2刺激BRCA 1的表达，敲低Nrf 2减弱BRCA 1的表达。Nrf 2还与CBP和p300相互作用形成一种活性转录复合物，该复合物可结合BRCA 1启动子上的ARE（antioxidant response element）位点，并通过诱导组蛋白乙酰化激活其转录。我们的发现可能有助于更好地了解乳腺癌的发展。
BRCA1 is closely related to the pathogenesis of breast cancer. The activity of BRCA1 promoter is regulated by transcriptional factors. The transcription factor Nrf2 (Nuclear factor-erythroid-2p45-related factor 2) is a potent transcriptional activator and plays a central role in inducible expression of many cytoprotective genes. In this report, we found that over-expression of Nrf2 stimulated BRCA1 expression, knockdown of Nrf2 attenuated BRCA1 expression. Nrf2 also interacted with CBP and p300 to form an active transcription complex, which could bind to the ARE (antioxidant response element) site on the BRCA1 promoter and activate its transcription by inducing histone acetylation. Our finding could lead to a better understanding of the development of breast cancer.