Ipsilateral connections of the ventral premotor cortex in a new world primate
Ipsilateral connections of the ventral premotor cortex in a new world primate
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DOI：
10.1002/cne.20875
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发表时间：
2006-04-01
影响因子：
2.5
通讯作者：
Nudo, RJ
中科院分区：
文献类型：
--
作者：
Dancause, N;Barbay, S;Nudo, RJ
本研究描述了成年松鼠猴腹侧运动前区皮质（PMV）与同侧半球不同皮质区的联系模式。具体而言，我们1）量化了PMv远端前肢表征与同侧皮层其他区域共享的输入和输出的比例，2）定义了PMv连接模式与初级运动皮层（M1），初级体感皮层（S1）和辅助运动区（SMA）中远端前肢表征位置的关系。皮质内微刺激技术（ICMS）被用于四个实验幼稚猴，以确定M1，PMV，SMA前肢运动的代表。多单位记录技术和髓鞘染色被用来确定S1手的代表。然后，将生物素化葡聚糖胺（BDA; 10，000 MW）注射到PMv远端前肢代表的中心。切向切片后，记录BDA标记的细胞体和终末终扣的分布。在M1中，标记遵循喙外侧模式，主要是离开尾内侧M1未标记。胞体和终端的定量显示，两个领域共享与PMV的主要连接：M1和额区直接喙PMV，指定为额喙区（FR）。与后一个区域的连接以前没有描述过。发现与PMd、SMA、前盖和后盖/下顶叶区的中度连接。在中央前皮质和顶叶皮质的不同区域（包括S1）发现了微小的连接。没有统计学差异的比例之间的输入和输出的任何位置进行了观察，支持PMV皮质内连接的互惠性。
The present study describes the pattern of connections of the ventral premotor cortex (PMv) with various cortical regions of the ipsilateral hemisphere in adult squirrel monkeys. Particularly, we 1) quantified the proportion of inputs and outputs that the PMv distal forelimb representation shares with other areas in the ipsilateral cortex and 2) defined the pattern of PMv connections with respect to the location of the distal forelimb representation in primary motor cortex (M1), primary somatosensory cortex (S1), and supplementary motor area (SMA). Intracortical microstimulation techniques (ICMS) were used in four experimentally naive monkeys to identify M1, PMv, and SMA forelimb movement representations. Multiunit recording techniques and myelin staining were used to identify the S1 hand representation. Then, biotinylated dextran amine (BDA; 10,000 MW) was injected in the center of the PMv distal forelimb representation. After tangential sectioning, the distribution of BDA-labeled cell bodies and terminal boutons was documented. In M1, labeling followed a rostrolateral pattern, largely leaving the caudomedial M1 unlabeled. Quantification of somata and terminals showed that two areas share major connections with PMv: M1 and frontal areas immediately rostral to PMv, designated as frontal rostral area (FR). Connections with this latter region have not been described previously. Moderate connections were found with PMd, SMA, anterior operculum, and posterior operculum/inferior parietal area. Minor connections were found with diverse areas of the precentral and parietal cortex, including S1. No statistical difference between the proportions of inputs and outputs for any location was observed, supporting the reciprocity of PMv intracortical connections.