VITAMIN-B12 ASSIMILATION FROM CHICKEN MEAT
VITAMIN-B12 ASSIMILATION FROM CHICKEN MEAT
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DOI：
10.1093/ajcn/31.5.825
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发表时间：
1978-01-01
影响因子：
7.1
通讯作者：
RIPLEY, D
中科院分区：
文献类型：
--
作者：
DOSCHERHOLMEN, A;MCMAHON, J;RIPLEY, D
用放射性B12体内标记的鸡肉被正常志愿者摄入。通过粪便排泄法测量的吸收与晶体放射性氰钴胺和羊肉的吸收相似，但超过了鸡蛋的吸收。肠胃外注射1000 μ g未标记的维生素B12不干扰从肉中吸收放射性B12。尿中的放射性与口服放射性羟钴胺素和维生素B12辅酶后的放射性一样低，表明放射性B12以辅酶形式存在于肉类中，或在烹饪和消化过程中转化为稳定的羟仿。恶性贫血患者在使用鸡肉进行的标准化尿排泄试验中显示出不显著的尿放射性;单纯胃无氯血症和胃部分切除术患者的尿放射性低于正常值，尽管他们对结晶放射性氰钴胺的吸收正常。在这些受试者中观察到的低于正常的血清维生素B12浓度可能是由于食物中维生素B12的吸收受损。
Chicken meat labeled in vivo with radio-B12 was ingested by normal volunteers. The absorption, measured by the fecal excretion method, was similar to that reported for crystalline radiocyanocobalamin and for mutton, but exceeded that from eggs. Parenteral injection of 1000 .mu.g of nonlabeled vitamin B12 did not interfere with the absorption of the radio-B12 from the meat. The urinary radioactivities, which were as low as those seen after oral administration of radioactive hydroxocobalamin and vitamin B12 coenzyme, suggested that the radio-B12 was present in meat in coenzyme form or was converted into the stable hydroxoform during the process of cooking and digestion. Patients with pernicious anemia showed insignificant urinary radioactivities in a standardized urinary excretion test using chicken meat; subjects with simple gastric achlorhydria and partial gastrectomy had subnormal values, although their absorption of crystalline radiocyanocobalamin was normal. The subnormal serum vitamin B12 concentration seen in these latter subjects may be due to impaired assimilation of vitamin B12 from food.