Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing.
Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing.
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DOI：
10.1038/nn.4131
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发表时间：
2015-11
影响因子：
25
通讯作者：
Luo L
中科院分区：
文献类型：
--
作者：
DeNardo LA;Berns DS;DeLoach K;Luo L
新皮层回路中的信息处理需要在广泛的空间尺度上整合输入，从局部微回路到远距离皮层和皮层下连接。我们使用狂犬病病毒为基础的跨突触追踪，分析在小鼠桶皮质和内侧前额叶皮质（mPFC）的锥体神经元的本地和远程输入的层状分布。在桶状皮质中的新发现包括从第3层（L3）到L 6的大量输入，普遍的跨层抑制输入，以及分别优先从输入皮质区的L2/3或L5/6到L2/3或L5/6的长距离输入。这些层特异性输入模式在很大程度上独立于受体神经元中的NMDA受体功能。mPFC L5比桶皮质L5接受更多的长程输入和更多的局部抑制性输入。这些结果提供了新的见解的组织和发展的新皮层网络，并确定重要的差异，在电路组织的感觉和关联皮层。
Information processing in neocortical circuits requires integrating inputs over a wide range of spatial scales, from local microcircuits to long-range cortical and subcortical connections. We used rabies virus-based trans-synaptic tracing to analyze the laminar distribution of local and long-range inputs to pyramidal neurons in the mouse barrel cortex and medial prefrontal cortex (mPFC). New findings in barrel cortex include substantial inputs from layer 3 (L3) to L6, prevalent translaminar inhibitory inputs, and long-range inputs to L2/3 or L5/6 preferentially from L2/3 or L5/6 of input cortical areas, respectively. These layer-specific input patterns are largely independent of NMDA receptor function in the recipient neurons. mPFC L5 receive proportionally more long-range inputs and more local inhibitory inputs than barrel cortex L5. These results provide new insight into the organization and development of neocortical networks and identify important differences in the circuit organization in sensory and association cortices.