Rational design of peptide-based implants for corneal bioengineering.
Rational design of peptide-based implants for corneal bioengineering.
复制标题
DOI：
10.1016/j.copbio.2023.102947
复制
发表时间：
2023-05
影响因子：
7.7
通讯作者：
Bapan Pramanik;M. M. Islam-M.;H. Patra
中科院分区：
文献类型：
--
作者：
Bapan Pramanik;M. M. Islam-M.;H. Patra
突出显示用于角膜植入物的肽和胶原样肽平台和策略。综述了这些植入物的物理和机械性能。重点介绍了创造角膜替代物和植入物的创新策略。强调了临床前和临床验证的要求和策略。讨论了未来角膜替代物的肽基植入物的更大前景。受损角膜的再生可以挽救视力，数百万患者。这些病人大部分都在等待移植供体角膜或合适的替代品以恢复视力。尽管供体角膜移植是临床上最受欢迎的治疗方法，但根据大流行前的估计，供体角膜短缺导致每70名患者中有近69名患者无法获得治疗，等待移植的名单每年急剧增加。因此，角膜置换术正在成为一种尖端的替代策略。鉴于肽，特别是具有生物活性功能基序的胶原蛋白样肽和肽两亲物，通过其分级自组装倾向获得所需的纳米至宏观3D结构，为角膜组织工程和促进再生展示了有希望的途径。在这里，我们分析了合理的肽设计，自组装，和策略的肽/肽为基础的纳米级构建块，以创建细胞外基质模拟植入物的角膜功能再生。
HighlightsPeptides and Collagen-like peptides platform and strategy for corneal implants demonstrated.The optimality of optical, physical and mechanical properties of such implants are summarised.Highlights on innovative strategies to create corneal substitute and implants.Requirements and strategy for preclinical and clinical validation highlighted.The bigger picture for peptide based implants for future corneal substitute is discussed.Regeneration of damaged cornea can save vision for millions of patients. Most of these patients are waiting for transplantation of a donor cornea or suitable substitute to restore vision. Although donor cornea transplantation is the most clinically accepted treatment, shortage of donor cornea results in almost 69 out of every 70 patients untreated with the waiting list for transplantation drastically increasing every year according to a prepandemic estimation. Therefore, corneal replacements are coming up as a cutting-edge alternative strategy. In view of the peptides, especially collagen-like peptides and peptide amphiphiles with bioactive functional motifs demonstrate promising avenue for the corneal tissue engineering and promoting regeneration, by their hierarchical self-assembling propensity to acquire desired nano-to macroscale 3D architecture. Here, we analyze rational peptide designing, self-assembly, and strategies of peptide/peptide-based nanoscale building blocks to create the extracellular matrix mimetic implants for functional regeneration of the cornea.