THE CELLULAR BASIS OF HEARING - THE BIOPHYSICS OF HAIR-CELLS
THE CELLULAR BASIS OF HEARING - THE BIOPHYSICS OF HAIR-CELLS
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DOI：
10.1126/science.2414845
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
HUDSPETH, AJ
中科院分区：
文献类型：
--
作者：
HUDSPETH, AJ
听觉过程中的一个关键事件是通过毛细胞将机械刺激转换为电信号，毛细胞是内耳的感觉受体。刺激导致这些细胞的机械敏感细胞器（它们的毛束）中的离子通道快速开放。这些转导通道，这是非选择性渗透，直接兴奋的毛束位移。毛细胞选择性地响应于特定频率的刺激，这既是由于它们的毛束的机械特性，也是由于构成电谐振器的离子通道的集合。
A crucial event in the hearing process is the transduction of mechanical stimuli into electrical signals by hair cells, the sensory receptors of the internal ear. Stimulation results in the rapid opening of ionic channels in the mechanically sensitive organelles of these cells, their hair bundles. These transduction channels, which are nonselectively permeable, are directly excited by hair-bundle displacement. Hair cells are selectively responsive to particular frequencies of stimulation, both due to the mechanical properties of their hair bundles and because of an ensemble of ionic channels that constitute an electrical resonator.