Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability
Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability
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DOI：
10.1111/j.1365-2788.2004.00621.x
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发表时间：
2004-09-01
影响因子：
3.6
通讯作者：
Bassett, AS
中科院分区：
文献类型：
--
作者：
Greenwood, CMT;Husted, J;Bassett, AS
目前尚不清楚智力障碍（ID）是否与精神病性心境障碍或精神分裂症有更多的家族关系。L. S. Penrose对有两个或两个以上成员住进精神病院的家庭的大样本提供了一个独特的机会来调查轻度ID、精神分裂症和精神情感障碍之间的家族关系。方法对183对受影响亲属进行调查，包括轻度ID先证者（男95对，女88对）及其患有精神分裂症或精神情感性障碍的一、二级亲属。结果在智力障碍先证者中，诊断为精神分裂症的亲属（121人）是诊断为情感性障碍的亲属（62人）的近两倍。即使考虑到精神分裂症住院风险的增加（P = 0.005），这种精神分裂症的过量在统计上也是显著的，并且在不同的相对类型中是相当恒定的。患有精神疾病的一级亲属中，父母（n = 77）比兄弟姐妹（n = 51）或子女（n = 3）更有可能成为父母，但母子对的比例并不高。结论ID与精神分裂症的家族关系强于精神病性情感性障碍，为精神分裂症的神经发育假说提供了支持。
Background It is unknown whether intellectual disability (ID) is more familially related to psychotic mood disorders or schizophrenia. L. S. Penrose's large sample of families with two or more members admitted to psychiatric hospitals provided a unique opportunity to investigate the familial relationship between mild ID, schizophrenia and psychotic affective disorders.Method There were 183 affected relative pairs comprising probands with mild ID (95 male, 88 female) and their first or second degree relatives with schizophrenia or psychotic affective disorder.Results There were nearly twice as many relatives with a diagnosis of schizophrenia (n = 121) as relatives with affective disorders (n = 62) among the intellectually impaired probands. This excess of schizophrenia was statistically significant, even after accounting for the increased risk of hospitalization for schizophrenia (P = 0.005), and was fairly constant across the different relative types. First-degree relatives with either mental illness were more likely to be parents (n = 77) than siblings (n = 51) or children (n = 3), but there was no excess of mother-son pairs.Conclusions These results suggest a stronger familial relationship of ID with schizophrenia than psychotic affective disorder, and lend some support to the neurodevelopmental hypothesis of schizophrenia.