Kinetic properties of a sex pheromone-degrading enzyme: the sensillar esterase of Antheraea polyphemus.
Kinetic properties of a sex pheromone-degrading enzyme: the sensillar esterase of Antheraea polyphemus.
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DOI：
10.1073/pnas.82.24.8827
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发表时间：
1985-12
影响因子：
11.1
通讯作者：
Richard G. Vogt;L. Riddiford;Glenn D. Prestwich
中科院分区：
文献类型：
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作者：
Richard G. Vogt;L. Riddiford;Glenn D. Prestwich
行为和电生理证据表明，性信息素迅速失活的感觉毛启动后不久的动作电位尖峰。我们报告的分离和特性的性信息素降解酶的感觉毛的天蚕。在存在生理浓度的这种酶的情况下，信息素[（6 E，11 Z）-十六碳二烯乙酸酯]的估计半衰期为15毫秒。我们的研究结果表明，信息素接收的分子模型，其中以前报道的信息素结合蛋白作为信息素载体，和酶作为一个快速的信息素灭活剂，保持低刺激噪声水平内的感觉毛发。
Behavioral and electrophysiological evidence has suggested that sex pheromone is rapidly inactivated within the sensory hairs soon after initiation of the action-potential spike. We report the isolation and characterization of a sex-pheromone-degrading enzyme from the sensory hairs of the silkmoth Antheraea polyphemus. In the presence of this enzyme at physiological concentration, the pheromone [(6E,11Z)-hexadecadienyl acetate] has an estimated half-life of 15 msec. Our findings suggest a molecular model for pheromone reception in which a previously reported pheromone-binding protein acts as a pheromone carrier, and an enzyme acts as a rapid pheromone inactivator, maintaining a low stimulus noise level within the sensory hairs.