Patient-reported outcomes in topical field treatment of actinic keratosis in Swedish and Danish patients
Patient-reported outcomes in topical field treatment of actinic keratosis in Swedish and Danish patients
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DOI：
10.1080/09546634.2017.1329514
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Tennvall, Gunnel Ragnarson
中科院分区：
文献类型：
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作者：
Norrlid, Hanna;Norlin, Jenny M.;Tennvall, Gunnel Ragnarson
皮肤科的局部治疗可能是长期的，复杂的，并导致不遵守和不持久的处方治疗。因此，在随机临床试验（RCT）中观察到的临床疗效可能会在现实世界的临床实践中降低。本研究的目的是分析丹麦和瑞典常规临床实践中局部治疗光化性角化病（AK）的患者报告的治疗依从性、治疗满意度和健康相关生活质量（HRQoL）。根据常规临床实践，接受双氯芬酸凝胶、咪喹莫特或巨大戟醇甲基丁酸酯现场定向局部AK治疗的成人患者有资格参加观察性RAPID-ACT研究。通过医生和患者问卷收集数据，问卷包括经验证的工具，用于测量治疗满意度（TSQM-9）、治疗依从性（MMAS）和HRQoL（EQ-5D-5L、EQ-VAS、AKQoL）。总共纳入了来自丹麦和瑞典的446例患者。与接受双氯芬酸治疗的患者相比，Ingenol甲基丁酸酯患者报告了更高的治疗有效性满意度（p= 0.006），但无法确定治疗满意度的其他差异。治疗依从性普遍较高，但巨大戟醇甲基丁酸酯的依从性高于双氯芬酸（p
Topical treatments in dermatology can be long, complex and lead to nonadherence and nonpersistence to prescribed treatment. Clinical efficacy observed in randomized clinical trials (RCT) may therefore be reduced in real-world clinical practice. The objective of this study was to analyze patient-reported treatment adherence, treatment satisfaction and health-related quality of life (HRQoL) with topical treatments of actinic keratosis (AK) in routine clinical practice in Denmark and Sweden. Adult patients prescribed field-directed topical AK treatments with diclofenac gel, imiquimod or ingenol mebutate per routine clinical practice were eligible for the observational RAPID-ACT study. Data were collected through physician and patient questionnaires that included validated instruments to measure treatment satisfaction (TSQM-9), treatment adherence (MMAS) and HRQoL (EQ-5D-5L, EQ-VAS, AKQoL). In total, 446 patients from Denmark and Sweden were included. Ingenol mebutate patients reported a higher satisfaction with treatment effectiveness compared to patients treated with diclofenac (p=.006) while no other differences in treatment satisfaction could be determined. Treatment adherence was generally high, but higher for ingenol mebutate compared to both diclofenac (p