Prednisolone (30–60 mg/day) for diseases other than AD decreases amyloid &bgr;-peptides in CSF
Prednisolone (30–60 mg/day) for diseases other than AD decreases amyloid &bgr;-peptides in CSF
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泼尼松龙（30-60 毫克/天）用于治疗 AD 以外的疾病可减少脑脊液中的淀粉样β-肽
DOI：
10.1212/wnl.58.9.1415
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发表时间：
2002
期刊：
影响因子：
9.9
通讯作者：
S. Ikeda
中科院分区：
文献类型：
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作者：
T. Tokuda;T. Oide;A. Tamaoka;K. Ishii;S. Matsuno;S. Ikeda
研究了皮质类固醇对16例接受泼尼松龙（每日≥30 mg）治疗的非痴呆患者脑脊液中淀粉样肽（A）浓度的影响。治疗后CSF中Ax-40和Ax-42浓度均较治疗前明显降低（P < 0.002）。中剂量或高剂量的泼尼松龙治疗方案可减少人脑中A的产生或增加A的降解，值得在AD中进一步研究。
Abstract—The effect of corticosteroid on the concentration of amyloid &bgr;-peptide (A&bgr;) in human CSF obtained from 16 patients without dementia treated with prednisolone (≥30 mg daily) was studied. The concentrations of A&bgr;x–40 and A&bgr;x–42 in CSF decreased after treatment was started (p < 0.002). A moderate- or high-dose regimen of prednisolone decreases A&bgr; production or increases A&bgr; degradation in the human brain and deserves further study in AD.
与皮质类固醇治疗相关的脑出血复发的停止
DOI：
--
发表时间：
2000
期刊：
Amyloid 7・4
影响因子：
--
作者：
Ishii K;玉岡晃;玉岡晃;玉岡晃;玉岡晃;Ishii K;Ishii K;Watanabe M;吉田秀明;吉田秀明;松下正明;玉岡晃;玉岡晃;古庄健太郎;藤田祐之;Tokuda T;Fujita Y;Miyawaki K;Ishii K;Watanabe M;Matsuno S;Takahiko Tokuda;Fujita Y;Kyoko Miyawaki;玉岡晃;玉岡晃;玉岡晃;玉岡晃;玉岡晃;Tokuda T;Ishii K;星野幸子;河野豊;河野豊;Ishii K;Marsuno S;原田祐嗣;玉岡晃;玉岡晃;Kazuhiro Ishii;Ishii K;Sayoko Matsuno;Takahiko Tokuda;Harada H;Hoshi K
通讯作者：
Hoshi K