CONTROLLING ELEMENTS IN THE MOUSE .5. LINKAGE TESTS WITH X-LINKED GENES
CONTROLLING ELEMENTS IN THE MOUSE .5. LINKAGE TESTS WITH X-LINKED GENES
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DOI：
10.1017/s0016672300020401
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发表时间：
1981-01-01
影响因子：
1.5
通讯作者：
PAPWORTH, D
中科院分区：
文献类型：
--
作者：
CATTANACH, BM;PAPWORTH, D
先前的研究表明，小鼠X染色体基因座Xce与Is（X; 7）Ct X-常染色体易位密切相关，它导致非随机X染色体失活。这将它放置在断点一侧的Ta附近或另一侧的jp附近。与Movbr和Ta的连锁试验表明，该位点位于Ta附近。C3 H/HeH X染色体显然携带该基因的Xcea等位基因，JU/FaCt和C57 BL/GoH X染色体携带Xceb等位基因，并且由各种其他研究者观察到的X连锁基因的杂合表型的X连锁修饰显然都可归因于Xce基因座的差异。还提供了母亲对Movbr表型的影响的证据。这可能独立于X-失活过程，可能是通过不同水平的铜在牛奶中的影响，在生命早期的突变体毛色的年轻人。
Previous studies showed that the mouse X chromosomal locus, Xce, which causes non-random X chromosome inactivation, is closely linked to the Is(X; 7)Ct X-autosome translocation. This placed it either near Ta on 1 side of the breakpoint or near jp on the other. Linkage tests with Movbr and Ta now demonstrate that the locus lies close to Ta. The C3H/HeH X chromosome evidently carries the Xcea allele of this gene and the JU/FaCt and C57BL/GoH X chromosomes carry the Xceb allele, and the X-linked modification of the heterozygous phenotypes of X-linked genes observed by various other investigators apparently are all attributable to differences at the Xce locus. Evidence of a maternal influence upon Movbr phenotypes is also presented. This may operate independently of the X-inactivation process, probably through an effect of differing levels of Cu in the milk in early life upon the mutant coat color in the young.