GLUTATHIONE .9. NEW THIOL-OXIDIZING AGENTS - DIP, DIP+1, DIP+2
GLUTATHIONE .9. NEW THIOL-OXIDIZING AGENTS - DIP, DIP+1, DIP+2
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DOI：
10.1016/s0006-291x(74)80213-5
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发表时间：
1974-01-01
影响因子：
3.1
通讯作者：
LEVY, L
中科院分区：
文献类型：
--
作者：
KOSOWER, EM;KOSOWER, NS;LEVY, L
新的硫醇氧化剂DIP（diazene dicarboxylic acid bis（N '-methylpiperazide））、DIP+1（DIP的N'-methyl iodide salt）和DIP+2（bis-N '-methyl iodide salt of DIP）已应用于人红细胞悬液。在20°C下，DIP导致细胞内谷胱甘肽GSH的相当快速的氧化。虽然DIP+1和DIP+2对GSH的反应性略高于DIP，但这两种药物都不会引起细胞内GSH的任何变化。概述了新系列的可能应用。
New thiol-oxidizing agents, DIP (diazene dicarboxylic acid bis(N′-methylpiperazide), DIP+1(N′-methyl iodide salt of DIP), and DIP+2 (bis-N′-methyl iodide salt of DIP) have been applied to human red blood cell suspensions. At 20°C, DIP leads to fairly rapid oxidation of intracellular glutathione, GSH. Although both DIP+1 and DIP+2 are slightly more reactive towards GSH than DIP, neither agent causes any change in intracellular GSH. Possible applications of the new series are outlined.