Systems approaches to investigate the role of NF-κB signaling in aging.
Systems approaches to investigate the role of NF-κB signaling in aging.
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DOI：
10.1042/bcj20210547
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发表时间：
2022-01-28
期刊：
影响因子：
--
通讯作者：
Okada M
中科院分区：
文献类型：
--
作者：
Haga M;Okada M
核因子-核因子-核转录因子B(NF-κB，NF-κB)信号通路是目前研究最多的炎症信号通路之一，其在衰老过程中的作用也引起了人们的广泛关注。由于衰老是一个复杂的现象，是一个多步骤过程的结果，所以NF-κB通路在衰老中的作用尚不清楚。为了阐明核因子-κB在衰老调节中的作用，人们采用了不同的系统生物学方法。多组学数据驱动的方法可以用来解释和澄清未知的机制，但不能单独产生机械性的监管结构。相比之下，将这种方法与数学建模方法相结合，可以识别感兴趣的现象的机理。单细胞技术的发展也有助于阐明NF-κB反应的异质性和潜在的机制。在这里，我们通过组学方法、单细胞分析和对NF-κB网络的数学建模来综述关于NF-κB调节衰老的理解的进展。
The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways related to inflammation, and its involvement in aging has attracted considerable attention. As aging is a complex phenomenon and is the result of a multi-step process, the involvement of the NF-κB pathway in aging remains unclear. To elucidate the role of NF-κB in the regulation of aging, different systems biology approaches have been employed. A multi-omics data-driven approach can be used to interpret and clarify unknown mechanisms but cannot generate mechanistic regulatory structures alone. In contrast, combining this approach with a mathematical modeling approach can identify the mechanistics of the phenomena of interest. The development of single-cell technologies has also helped clarify the heterogeneity of the NF-κB response and underlying mechanisms. Here, we review advances in the understanding of the regulation of aging by NF-κB by focusing on omics approaches, single-cell analysis, and mathematical modeling of the NF-κB network.