Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord.
Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord.
复制标题
DOI：
10.1007/3-211-30714-1_67
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
H. S. Sharma;P. Vannemreddy;R. Patnaik;R. Patnaik;Patnaik Sk;S. Mohanty
中科院分区：
文献类型：
--
作者：
H. S. Sharma;P. Vannemreddy;R. Patnaik;R. Patnaik;Patnaik Sk;S. Mohanty
通过调节大鼠组胺 H1、H2 和 H3 受体，研究组胺在脊髓损伤 (SCI) 后水肿形成、血脊髓屏障 (BSCB) 通透性和脊髓血流 (SCBF) 中的作用。 T10-11 水平脊髓的局灶性创伤显着增加了 T9 和 T12 节段的脊髓水肿形成、BSCB 对蛋白质示踪剂的通透性以及 SCBF 减少。用组胺 H1 受体拮抗剂美吡拉明（1 mg、5 mg 和 10 mg/kg，腹腔注射）进行预处理并没有减弱 SCI 后的脊柱病理生理学。用西咪替丁或雷尼替丁（损伤前 30 分钟 1 mg、5 mg 或 10 mg/kg）阻断组胺 H2 受体，以剂量依赖性方式显着减少早期病理生理事件。相同剂量下，雷尼替丁的作用远优于西咪替丁。用组胺 H3 受体激动剂 α-甲基组胺（1 mg 和 2 mg/kg/腹腔注射）进行预处理，可抑制中枢神经系统中组胺的合成和释放，阻止 SCI 后水肿形成、BSCB 分解和 SCBF 紊乱。组胺H3激动剂的最低剂量是最有效的。用硫哌丁胺（1 mg、5 mg/kg，腹膜内注射）阻断组胺 H3 受体会加剧脊髓病理。这些观察结果表明，刺激组胺 H3 受体和阻断组胺 H2 受体在 SCI 中具有神经保护作用。
The role of histamine in edema formation, blood-spinal cord barrier (BSCB) permeability, and spinal cord blood flow (SCBF) following spinal cord injury (SCI) was examined using modulation of histamine H1, H2, and H3receptors in the rat. Focal trauma to the spinal cord at the T10–11 level significantly increased spinal cord edema formation, BSCB permeability to protein tracers and SCBF reduction in the T9 and T12 segments. Pretreatment with histamine H1receptor antagonist mepyramine (1 mg, 5 mg, and 10 mg/kg, i.p.) did not attenuate spinal pathophysiology following SCI. Blockade of histamine H2receptors with cimetidine or ranitidine (1 mg, 5 mg, or 10 mg/kg 30 minutes before injury) significantly reduced early pathophysiological events in a dose dependent manner. The effects of ranitidine were far superior to cimetidine in identical doses. Pretreatment with a histamine H3receptor agonist α-methylhistamine (1 mg and 2 mg/kg/i.p.), that inhibits histamine synthesis and release in the CNS, thwarted edema formation, BSCB breakdown, and SCBF disturbances after SCI. The lowest dose of histamine H3agonist was most effective. Blockade of histamine H3receptors with thioperamide (1 mg, 5 mg/kg, i.p.) exacerbated spinal cord pathology. These observations suggest that stimulation of histamine H3receptors and blockade of histamine H2receptors is neuroprotective in SCI.