ULTRASTRUCTURE OF ENLARGED CECUM IN GERMFREE RATS
ULTRASTRUCTURE OF ENLARGED CECUM IN GERMFREE RATS
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DOI：
10.1007/bf00340589
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发表时间：
1971-01-01
期刊：
影响因子：
--
通讯作者：
MAUNSBACH, AB
中科院分区：
文献类型：
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作者：
GUSTAFSSON, BE;MAUNSBACH, AB
通过光学显微镜、扫描和透射电子显微镜研究，无菌大鼠的盲肠在许多方面不同于常规大鼠的盲肠。无菌大鼠的上皮细胞比常规大鼠的类似细胞更高，细胞核更大，微绒毛更长。无菌大鼠的盲肠粘膜在Lieberkühn隐窝的排列方面比常规大鼠的粘膜表现出更大的变异性。有些隐窝呈漏斗状，靠近粘膜表面与相邻的类似隐窝相连，形成长谷。在粘膜表面的隆起区域，开口较窄的隐窝。无菌动物的固有层缺乏浆细胞，但富含肥大细胞。无菌动物的外图尼卡肌层肥大，而普通大鼠的盲肠腔中含有大量不同形态的细菌。然而，Lieberkühn隐窝的内腔仅含有一种类型的细长细菌，它们大量存在。这一发现表明，共生关系可能是特别重要的，在盲肠的Lieberkühn隐窝。
The cecum of germfree rats, as studied by light microscopy and scanning and transmission electron microscopy, differs in many respects from the cecum of conventional rats. Epithelial cells in germfree rats are taller and have larger nuclei and longer microvilli than similar cells in conventional rats. The cecal mucosa of germfree rats shows a larger variability in the arrangement of the crypts of Lieberkühn than does the mucosa of conventional rats. Some crypts are funnel-shaped and connected close to the mucosal surface with adjacent similar crypts to form long valleys. Less wide crypts open on elevated regions of the mucosal surface. The lamina propria of germfree animals is devoid of plasma cells but rich in mast cells. Germfree animals show hypertrophy of the tunica muscularis externa.In conventional rats the cecal lumen contains a large variety of morphologically different bacteria. However, the lumen of the crypts of Lieberkühn contains only one type of elongated bacteria, which are present in large amounts. This finding suggests that symbiotic relations may be of particular importance in the crypts of Lieberkühn in the cecum.