Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3,4-tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice
Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3,4-tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice
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DOI：
10.1006/nlme.1998.3883
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发表时间：
1999-05-01
影响因子：
2.7
通讯作者：
Pavone, F
中科院分区：
文献类型：
--
作者：
Capone, F;Oliverio, A;Pavone, F
乙酰胆碱酯酶可逆抑制剂N-辛基-1，2，3，4-四氢-9-氨基吖啶（THA-C8）是一种新合成的他克林（THA）衍生物，其分子结构中的烷基链改善了该化合物对中枢神经系统的渗透性。THA-C8（0.1-5 mg/kg）在3 mg/kg的剂量下显著降低了CD 1小鼠的自发运动活动。此外，THA-C8（0.2-2 mg/kg）在不影响运动的剂量（0.25、0.3、1 mg/kg）下显著改善穿梭箱回避获得，并且远低于动物模型中报道的对THA有效的剂量。从报告的数据来看，这种新化合物似乎对治疗目的很有意义。(C)北京：科学出版社.
The acetylcholinesterase reversible inhibitor N-octyl-1,2,3,4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1-5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2-2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes. (C) 1999 Academic Press.