Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion.
Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion.
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DOI：
10.1038/s41598-017-10815-y
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发表时间：
2017-09-12
影响因子：
4.6
通讯作者：
Nakaji S
中科院分区：
文献类型：
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作者：
Daimon M;Kamba A;Murakami H;Mizushiri S;Osonoi S;Matsuki K;Sato E;Tanabe J;Takayasu S;Matsuhashi Y;Yanagimachi M;Terui K;Kageyama K;Tokuda I;Kurauchi S;Nakaji S
下丘脑-垂体-肾上腺 (HPA) 轴与肾素-血管紧张素-醛固酮系统 (RAAS) 之间的关联如何影响葡萄糖代谢尚未在一般人群中得到充分研究。 2015 年基于人群的 Iwaki 研究的参与者已入组（人数：1,016 人；年龄：54.4±15.1 岁）。主成分 (PC) 分析确定了两个 PC：PC1 代表 HPA 轴（血清皮质醇）和 RAAS（血浆醛固酮）的整体水平，PC2 代表 HPA 轴相对于 RAAS（HPA 轴优势）的水平。我们使用胰岛素敏感性降低 (HOMA-R) 和分泌 (HOMA-β) 的稳态模型评估指数检查了这些 PC 与葡萄糖代谢之间的关联。单变量线性回归分析显示 PC2 和 HOMA-β 之间存在相关性 (β = −0.248, p < 0.0001)，但 PC1 和 HOMA-β 之间不存在相关性 (β = −0.004, p = 0.9048)。调整多个因素后，PC2 和 HOMA-β 之间的相关性仍然存在（β = −0.101，p = 0.0003）。 PC 和 HOMA-R 之间没有发现相关性。当根据 PC2 对受试者进行三分位时，在调整多个因素后，最高三分位数（定义为 HOMA-β 的下三分之一 (≤68.9)）胰岛素分泌减少的风险高于最低三分位数（比值比，2.00；95% 置信区间，1.35-2.97）。 HPA 轴优势与日本人群的胰岛素分泌减少有关。
How the association between the hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin-aldosterone system (RAAS) affects glucose metabolism were not well examined in a general population. Participants of the population-based 2015 Iwaki study were enrolled (n: 1,016; age: 54.4 ± 15.1 years). Principal component (PC) analysis identified two PCs: PC1 represented levels of the HPA axis (serum cortisol) and the RAAS (plasma aldosterone) as a whole, and PC2 represented the HPA axis relative to the RAAS (HPA axis dominance). We examined the association between these PCs and glucose metabolism using homeostasis model assessment indices of reduced insulin sensitivity (HOMA-R) and secretion (HOMA-β). Univariate linear regression analyses showed a correlation between PC2 and HOMA-β (β = −0.248, p < 0.0001), but not between PC1 and HOMA-β (β = −0.004, p = 0.9048). The correration between PC2 and HOMA-β persisted after adjustment for multiple factors (β = −0.101, p = 0.0003). No correlations were found between the PCs and HOMA-R. When subjects were tertiled based on PC2, the highest tertile was at greater risk of decreased insulin secretion (defined as the lower one third of HOMA-β (≤68.9)) than the lowest tertile after adjustment for multiple factors (odds ratio, 2.00; 95% confidence interval, 1.35–2.97). The HPA axis dominance is associated with decreased insulin secretion in a Japanese population.
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影响因子：
3.7
作者：
Blondeau B;Sahly I;Massouridès E;Singh-Estivalet A;Valtat B;Dorchene D;Jaisser F;Bréant B;Tronche F
通讯作者：
Tronche F
影响因子：
2
作者：
Liu, Wei;Katz, David A.;Dutta, Sandeep
通讯作者：
Dutta, Sandeep
影响因子：
9.8
作者：
LONGANO, CA;FLETCHER, HP
通讯作者：
FLETCHER, HP
影响因子：
5.8
作者：
Garg, Rajesh;Hurwitz, Shelley;Adler, Gail K.
通讯作者：
Adler, Gail K.
影响因子：
--
作者：
BEARD, JC;HALTER, JB;PORTE, D
通讯作者：
PORTE, D