Expression of P-selectin, von Willebrand and endothelin-1 after carotid artery stenting.
Expression of P-selectin, von Willebrand and endothelin-1 after carotid artery stenting.
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DOI：
10.1024/0301-1526/a000094
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发表时间：
2011-05
期刊：
影响因子：
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通讯作者：
Z. Xia;H. Yang;H. Qu;W. Cheng;L-X Wang
中科院分区：
文献类型：
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作者：
Z. Xia;H. Yang;H. Qu;W. Cheng;L-X Wang
本研究旨在探讨颈动脉支架植入术（CAS）对血浆p -选择素、血管性血友病（vWF）和内皮素-1水平的影响。患者和方法67例接受CAS治疗的患者分为1组（单个病变1个支架，n = 38）和2组（复杂病变2个支架，n = 29）。分别于CAS前、支架植入术后1 h、6h、24 h、2周检测p -选择素、vWF、内皮素-1水平。结果61例患者完成1年随访。再狭窄14例（23%），其中3例（4.8%）血管腔再狭窄50%。所有患者在CAS后P-选择素、vWF和内皮素-1水平均立即升高（P < 0.05）。再狭窄组24 h vWF高于非再狭窄组（P < 0.05）。结论CAS导致血浆p -选择素、vWF和内皮素-1显著升高。cas后p -选择素、vWF和内皮素-1水平与内皮损伤程度有关。它们是否与治疗后12个月的再狭窄有关，需要进一步调查。
BACKGROUND This study was designed to investigate the impact of carotid artery stenting (CAS) on plasma levels of P-selectin, von Willebrand (vWF) and endothelin-1. PATIENTS AND METHODS Sixty-seven patients who received CAS were divided into group 1 (one stent for a simple lesion, n = 38) and group 2 (two stents for complex lesions, n = 29). The levels of P-selectin, vWF and endothelin-1 were measured before CAS, 1 h, 6h, 24 h and 2 weeks after the stenting. RESULTS Sixty-one patients completed one-year follow up. Restenosis was noted in 14 (23 %) patients, among these three (4.8 %) had a restenosis of > 50 % of the vascular lumen. In all patients, the levels of P-selectin, vWF and endothelin-1 increased immediately after CAS (P 0.05). The 24 h vWF in patients with restenosis were higher than in non-restenosis group (P < 0.05). CONCLUSIONS CAS results in a significant increase in plasma P-selectin, vWF and endothelin-1. The post-CAS levels of P-selectin, vWF and endothelin-1 are related to the extent of endothelial injury. Whether they are associated with restenosis 12 months after the treatment requires further investigation.