Surveillance for bacterial meningitis by means of polymerase chain reaction.
Surveillance for bacterial meningitis by means of polymerase chain reaction.
复制标题
通过聚合酶链反应监测细菌性脑膜炎。
DOI：
10.1086/426448
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Gotschlich,EmilC
中科院分区：
文献类型：
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作者：
Robbins,JohnB;Schneerson,Rachel;Gotschlich,EmilC
在撒哈拉以南非洲“脑膜炎带”的代表国家布基纳法索实施PCR技术研究细菌性脑膜炎的发病率、年龄分布和病因，揭示了该疾病的几个重要方面[1]。该研究是在流行性脑膜炎球菌性脑膜炎异常流行期间进行的，其中 W135 血清群（而不是 A 血清群）是主要病原体。采用 PCR 技术以及培养和荚膜多糖抗原检测进行的基于人群的监测，可以提高病原体鉴定的检测灵敏度。虽然人们的注意力几乎完全集中在流行性 A 组脑膜炎球菌性脑膜炎上，但地方性细菌性脑膜炎是一种常见疾病，由在发展中国家引起细菌性脑膜炎的相同病原体（即肺炎球菌和 B 型流感嗜血杆菌，以及脑膜炎球菌）引起[2]。地方性细菌性脑膜炎的总发病率为每年约 0.05%。或者，
The implementation of PCR technology to study the incidence, age distribution, and etiology of bacterial meningitis in Burkina Faso, a country that is representative of the “meningitis belt” of sub-Saharan Africa, unearthed several important aspects of this disease [1]. The study was conducted during an unusual epidemic of meningococcal meningitis in which serogroup W135, rather than serogroup A, was the predominant pathogen. Populationbased surveillance with PCR technology, as well as with culture and capsular polysaccharide antigen detection, permitted greater test sensitivity for the identification of pathogens.Whereas attention has been almost entirely focused on epidemic group A meningococcal meningitis, endemic bacterial meningitis is a common disease that is caused by the same pathogens that cause bacterial meningitis in developing countries (ie, pneumococci and Haemophilus influenzae type b, as well as meningococci)[2]. The overall incidence of endemic bacterial meningitis is∼ 0.05% per year. Or,