Predicting metabolic adaptation, body weight change, and energy intake in humans
Predicting metabolic adaptation, body weight change, and energy intake in humans
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DOI：
10.1152/ajpendo.00559.2009
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发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Hall, Kevin D.
中科院分区：
文献类型：
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作者：
Hall, Kevin D.
霍尔 KD.预测人类的代谢适应、体重变化和能量摄入。 Am J Physiol Endocrinol Metab 298：E449-E466，2010。首次发表于 2009 年 11 月 24 日； doi:10.1152/ajpendo.00559.2009.-碳水化合物、脂肪和蛋白质代谢之间复杂的相互作用是人体适应各种饮食的卓越能力的基础。但这些常量营养素的摄入量和利用率之间的任何不平衡都会导致体重和成分的变化。在这里，我提出了第一个计算模型，该模型模拟饮食扰动如何导致燃料选择和能量消耗的适应，从而预测肥胖和非肥胖男性和女性的体重和成分变化。除了每个受试者组的初始条件（例如初始体重和体脂肪量）之外，没有调整模型参数来拟合这些数据。该模型首次真实模拟了饮食扰动如何导致全身能量消耗、燃料选择和各种代谢通量的适应，最终导致体重变化。经过验证的模型用于估计长期减肥干预期间自由生活的能量摄入量，这是以前从未准确测量过的变量。
Hall KD. Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrinol Metab 298: E449-E466, 2010. First published November 24, 2009; doi:10.1152/ajpendo.00559.2009.-Complex interactions between carbohydrate, fat, and protein metabolism underlie the body's remarkable ability to adapt to a variety of diets. But any imbalances between the intake and utilization rates of these macronutrients will result in changes in body weight and composition. Here, I present the first computational model that simulates how diet perturbations result in adaptations of fuel selection and energy expenditure that predict body weight and composition changes in both obese and nonobese men and women. No model parameters were adjusted to fit these data other than the initial conditions for each subject group (e.g., initial body weight and body fat mass). The model provides the first realistic simulations of how diet perturbations result in adaptations of whole body energy expenditure, fuel selection, and various metabolic fluxes that ultimately give rise to body weight change. The validated model was used to estimate free-living energy intake during a long-term weight loss intervention, a variable that has never previously been measured accurately.