ADVANCES IN IN VIVO EPR TOOTH BIODOSIMETRY: MEETING THE TARGETS FOR INITIAL TRIAGE FOLLOWING A LARGE-SCALE RADIATION EVENT
ADVANCES IN IN VIVO EPR TOOTH BIODOSIMETRY: MEETING THE TARGETS FOR INITIAL TRIAGE FOLLOWING A LARGE-SCALE RADIATION EVENT
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DOI：
10.1093/rpd/ncw165
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发表时间：
2016-12-01
影响因子：
1
通讯作者：
Swartz, Harold M.
中科院分区：
文献类型：
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作者：
Flood, Ann Barry;Williams, Benjamin B.;Swartz, Harold M.
使用电子顺磁共振(EPR)的活体牙齿生物剂量学的发展和演变中的几个重要最新进展使其性能达到或超过了美国在大规模辐射事件中对准确性和易操作性以及吞吐量的目标要求。基于人体工程学的磁铁变化，再加上磁铁旋转的开发和自动收集数据的先进软件，使测量变得更容易、更快。从开始到结束，测量总共需要5分钟，数据采集不到3分钟。同时，根据灵敏度、特异度和ROC曲线下面积的衡量标准，对大人口进行分类的数据的准确性有所提高。将这些标准应用于预期人群，EPR活体牙齿生物剂量学具有与所谓的‘金标准’(双着丝粒染色体分析)大致相同的诊断准确性。其他改进包括光谱仪的小型化，从而创造出更轻、更紧凑的原型，适合运输用于护理点(POC)操作，并且可以通过单个标准电源插座操作。谐振器的其他改进，包括使用连接在门牙上的一次性传感环路，产生了一种生物剂量测量方法，只需简单的5步工作流程，只需几分钟的培训(可以作为培训视频内置到仪器中)，就可以快速进行测量。总而言之，最近的进步使这一原型能够达到或超过美国联邦政府在大型活动中进行POC生物剂量测量的推荐目标。
Several important recent advances in the development and evolution of in vivo Tooth Biodosimetry using Electron Paramagnetic Resonance (EPR) allow its performance to meet or exceed the U.S. targeted requirements for accuracy and ease of operation and throughput in a large-scale radiation event. Ergonomically based changes to the magnet, coupled with the development of rotation of the magnet and advanced software to automate collection of data, have made it easier and faster to make a measurement. From start to finish, measurements require a total elapsed time of 5 min, with data acquisition taking place in less than 3 min. At the same time, the accuracy of the data for triage of large populations has improved, as indicated using the metrics of sensitivity, specificity and area under the ROC curve. Applying these standards to the intended population, EPR in vivo Tooth Biodosimetry has approximately the same diagnostic accuracy as the purported `gold standard' (dicentric chromosome assay). Other improvements include miniaturisation of the spectrometer, leading to the creation of a significantly lighter and more compact prototype that is suitable for transporting for Point of Care (POC) operation and that can be operated off a single standard power outlet. Additional advancements in the resonator, including use of a disposable sensing loop attached to the incisor tooth, have resulted in a biodosimetry method where measurements can be made quickly with a simple 5-step workflow and by people needing only a few minutes of training (which can be built into the instrument as a training video). In sum, recent advancements allow this prototype to meet or exceed the US Federal Government's recommended targets for POC biodosimetry in large-scale events.