A Prospective Study of Posttraumatic Stress Disorder Symptoms and Coronary Heart Disease in Women
A Prospective Study of Posttraumatic Stress Disorder Symptoms and Coronary Heart Disease in Women
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DOI：
10.1037/0278-6133.28.1.125
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Eaton, William W.
中科院分区：
文献类型：
--
作者：
Kubzansky, Laura D.;Koenen, Karestan C.;Eaton, William W.
目的：创伤后应激障碍（PTSD）反映了长期的应激反应和应激反应系统的失调，并被假设为增加患冠心病（CHD）的风险。尽管PTSD在女性中比男性更普遍，但没有研究在女性中验证过这一假设。本研究旨在研究是否更高水平的PTSD症状与女性冠心病发病风险增加有关。设计：一项前瞻性研究，使用来自巴尔的摩流行病学集水区研究队列的女性数据（n = 1059）。过去一年的创伤和相关的PTSD症状使用NIMH诊断访谈表进行评估。主要结果测量：14年随访至1996年期间发生的冠心病事件。结果如下：有五种或五种以上症状的女性发生冠心病的风险是无症状女性的三倍以上（年龄调整OR = 3.21，95%CI：1.29-7.98）。在控制了标准的冠状动脉危险因素以及抑郁或特质焦虑后，研究结果得以维持。总结：创伤后应激障碍症状可能对平民社区居住妇女的身体健康产生破坏性影响，高水平的创伤后应激障碍症状与冠心病相关发病率和死亡率的风险增加有关。
Objective: Posttraumatic stress disorder (PTSD) reflects a prolonged stress reaction and dysregulation of the stress response system and is hypothesized to increase risk of developing coronary heart disease (CHD). No study has tested this hypothesis in women even though PTSD is more prevalent among women than men. This study aims to examine whether higher levels of PTSD symptoms are associated with increased risk of incident CHD among women. Design: A prospective study using data from women participating in the Baltimore cohort of the Epidemiologic Catchment Area study (n = 1059). Past year trauma and associated PTSD symptoms were assessed using the NIMH Diagnostic Interview Schedule. Main Outcome Measures: Incident CHD occurring during the 14-year follow-up through 1996. Results: Women with five or more symptoms were at over three times the risk of incident CHD compared with those with no symptoms (age-adjusted OR = 3.21, 95% CI: 1.29-7.98). Findings were maintained after controlling for standard coronary risk factors as well as depression or trait anxiety. Conclusion: PTSD symptoms may have damaging effects on physical health for civilian community-dwelling women, with high levels of PTSD symptoms associated with increased risk of CHD-related morbidity and mortality.