Extracellular Matrix Regulation of Stem Cell Behavior.
Extracellular Matrix Regulation of Stem Cell Behavior.
复制标题
干细胞行为的细胞外基质调节。
DOI：
10.1007/s40778-016-0056-2
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发表时间：
2016
影响因子：
1.4
通讯作者：
Ffrench-Constant C
中科院分区：
文献类型：
--
作者：
Ahmed M;Ffrench-Constant C
干细胞通过促进内源性细胞修复或直接细胞移植在治疗许多疾病方面具有很大的前景。为了最大限度地发挥他们的潜力，了解调节他们行为的基本信号和机制至关重要。细胞外基质（ECM）是参与介导干细胞命运的一种这样的组分。最近的研究在理解干细胞-ECM相互作用方面取得了重大进展。技术的发展已经提供了更清晰的细胞如何感知和响应ECM，特别是基质的物理性质。这篇综述总结了最近的发展，ECM控制胚胎和成体干细胞行为的不同模式提供了说明性的例子。
Stem cells hold great promise in treating many diseases either through promoting endogenous cell repair or through direct cell transplants. In order to maximize their potential, understanding the fundamental signals and mechanisms that regulate their behavior is essential. The extracellular matrix (ECM) is one such component involved in mediating stem cell fate. Recent studies have made significant progress in understanding stem cell-ECM interactions. Technological developments have provided greater clarity in how cells may sense and respond to the ECM, in particular the physical properties of the matrix. This review summarizes recent developments, providing illustrative examples of the different modes with which the ECM controls both embryonic and adult stem cell behavior.