Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
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DOI：
10.1038/srep42289
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发表时间：
2017-02-20
影响因子：
4.6
通讯作者：
Aneja R
中科院分区：
文献类型：
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作者：
Ogden A;Garlapati C;Li XB;Turaga RC;Oprea-Ilies G;Wright N;Bhattarai S;Mittal K;Wetherilt CS;Krishnamurti U;Reid MD;Jones M;Gupta M;Osan R;Pattni S;Riaz A;Klimov S;Rao A;Cantuaria G;Rida PC;Aneja R
核KIFC 1（nKIFC 1）预测乳腺癌的预后较差，但其在种族不同的三阴性乳腺癌（TNBC）患者中的预后价值尚不清楚。因此，通过免疫组织化学方法评估了来自四家医院的163名非洲裔美国人（AA）和144名白色TNBC组织微阵列（TMA）中的nKIFC 1表达。在白色TNBC中，nKIFC 1与Ki 67显著相关，但在AA TNBC中不相关，表明nKIFC 1不仅仅是AA TNBC中增殖的替代物。在多变量考克斯模型中，高nKIFC 1加权指数（WI）与AA TNBC（而非白色TNBC）的总生存期（OS）、无进展生存期（PFS）和无远处转移生存期（DMFS）显著较差相关（风险比[HR]分别= 3.5、3.1和3.8; P分别= 0.01、0.009和0.007）。此外，KIFC 1敲低比白色TNBC细胞更严重地损害AA TNBC细胞中的迁移。总的来说，这些数据表明nKIFC 1 WI是AA TNBC患者预后不良的独立生物标志物，这可能是由于KIFC 1在AA TNBC细胞中迁移的必要性。
Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, nKIFC1 expression was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarrays (TMAs) pooled from four hospitals. nKIFC1 correlated significantly with Ki67 in White TNBCs but not in AA TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. High nKIFC1 weighted index (WI) was associated with significantly worse overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (Hazard Ratios [HRs] = 3.5, 3.1, and 3.8, respectively; P = 0.01, 0.009, and 0.007, respectively) in multivariable Cox models in AA TNBCs but not White TNBCs. Furthermore, KIFC1 knockdown more severely impaired migration in AA TNBC cells than White TNBC cells. Collectively, these data suggest that nKIFC1 WI an independent biomarker of poor prognosis in AA TNBC patients, potentially due to the necessity of KIFC1 for migration in AA TNBC cells.