The angiographic and clinical outcomes after coronary stenting in patients with metabolic syndrome
The angiographic and clinical outcomes after coronary stenting in patients with metabolic syndrome
复制标题
代谢综合征患者冠状动脉支架置入术后的血管造影和临床结果
DOI：
10.1016/j.atherosclerosis.2011.12.016
复制
发表时间：
2012-04-01
期刊：
影响因子：
5.3
通讯作者：
Cao, Kejiang
中科院分区：
文献类型：
--
作者：
Xu, Di;Guo, Yan;Cao, Kejiang
背景：代谢综合征（MetS）被认为是冠心病（CAD）的危险因素。但MetS对CAD患者支架植入后发病率和死亡率的影响仍不清楚。方法：本文对现有数据进行了荟萃分析，探讨MetS与支架植入后血管造影和临床结局风险之间的关系。结果：MetS与支架植入后全因死亡风险显著增加相关冠心病患者的心血管事件发生率（OR，2.17，95% CI，1.56-3.01）、病变内再狭窄（OR，1.35，95% CI，1.00-1.84）和主要心脏不良事件（MACE）（OR 1.35，95% CI 1.13-1.61）。即使植入药物洗脱支架（DES），MetS患者的全因死亡率（OR，2.25，95% CI，1.61-3.15）和MACE（OR 1.42，95% CI 1.14-1.76）风险仍显著增加。然而，心血管（CV）死亡率的OR（1.25，95% CI 0.71-2.22），MI（1.27，95% CI 0.87-1.85）和TLR（OR 1.21，95%CI 0.96-1.53）在代谢综合征患者和非代谢综合征患者之间无统计学差异。代谢综合征是冠心病患者支架植入后的重要危险因素。尽管DES植入降低了血管造影事件的发生率，但仍需要在适当治疗MetS方面取得进一步进展，以改善临床结局。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Background: Metabolic syndrome (MetS) is regarded as a risk factor for coronary artery disease (CAD). But the influence of MetS on morbidity and mortality after stent implantation in CAD patients remains unknown.Methods: This article presents a meta-analysis of available data on the association between the MetS and the risk of angiographic and clinical outcomes following stent implantation.Results: MetS was associated with a significant increased risk of post-stent all-cause mortality (odd ratio (OR), 2.17, 95% CI, 1.56-3.01), in-lesion restenosis (OR, 1.35, 95% CI, 1.00-1.84) and major adverse cardiac events (MACE) (OR 1.35, 95% CI 1.13-1.61) in CAD patients. Even with drug-eluting stent (DES) implantation, significant increased risk in all-cause mortality (OR, 2.25, 95% CI, 1.61-3.15) and MACE (OR 1.42, 95% CI 1.14-1.76) were remain in patients with MetS. However, the OR of cardiovascular (CV) mortality (1.25, 95% CI 0.71-2.22), MI (1.27, 95% CI 0.87-1.85) and TLR (OR 1.21, 95% CI 0.96-1.53) was not statistically different between the patients with and without metabolic syndrome.Conclusions: Metabolic syndrome is an important risk factor in patients with CAD following stent implantation. Although DES implantation decreased the incidence of angiographic events, further progress in adequate treatment of MetS is still required to improve the clinical outcome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.