Biodegradable mesoporous nanocomposites with dual-targeting function for enhanced anti-tumor therapy
Biodegradable mesoporous nanocomposites with dual-targeting function for enhanced anti-tumor therapy
复制标题
具有双靶向功能的生物可降解介孔纳米复合材料增强抗肿瘤治疗
DOI：
10.1016/j.jconrel.2021.11.044
复制
发表时间：
2021-12-04
影响因子：
10.8
通讯作者：
Shi, Kai
中科院分区：
文献类型：
--
作者：
Gao, Shan;Liu, Yuli;Shi, Kai
肿瘤相关巨噬细胞（TAM）是肿瘤中浸润白细胞的主要成分，通常在促进癌症发生和进展中发挥关键作用。肿瘤特异性微环境迫使肿瘤浸润表型向有利于肿瘤发展的方向进化，即M2样TAM的产生。因此，癌细胞和肿瘤微环境的双重干预成为肿瘤免疫治疗领域的研究热点。在这项贡献中，我们开发了用吲哚菁绿（ICG）封装的pH敏感介孔硅酸钙纳米复合材料（MCN），以实现由808 nm近红外（NIR）光触发的光热疗法（PTT）和光动力疗法（PDT）的有效结合。甘露糖和透明质酸移植的 MCN 特异性靶向 TAM 和肿瘤细胞，并在体外和体内促进细胞凋亡。本文揭示，用近红外辐射加载 ICG 的 MCN 可以产生有效的高温，并诱导靶细胞产生大量的细胞内单线态氧。这些结果表明，新型纳米平台被认为有助于将化疗药物递送至肿瘤微环境（TME），以增强肿瘤治疗的效果。
Tumor-associated macrophages (TAMs), the main components of infiltrating leukocytes in tumors, often play a key role in promoting cancer development and progression. The tumor-specific microenvironment forces the phenotype of tumor-infiltrating to evolve in a direction favorable to tumor development, that is, the generation of M2-like TAMs. Consequently, the dual intervention of cancer cells and tumor microenvironment has become a research hotspot in the field of tumor immunotherapy. In this contribution, we developed pH-sensitive meso-porous calcium silicate nanocomposites (MCNs) encapsulated with indocyanine green (ICG) to enable the effective combination of photothermal therapy (PTT) and photodynamic therapy (PDT) triggered by the 808 nm near-infrared (NIR) light. The mannose and hyaluronic acid-grafted MCNs specifically targeted TAMs and tumor cells and promoted cell apoptosis both in vitro and in vivo. This paper revealed that irradiation of ICG loaded MCNs with NIR can produce a potent hyperthermia and induce abundant intracellular singlet oxygen generation in the target cells. These results suggest that the novel nanoplatform is believed to facilitate the delivery of chemotherapeutic agents to the tumor microenvironment (TME) to enhance the effects of tumor treatment.