Endothelial Dysfunction in Systemic Lupus Erythematosus: Evaluation with 13N-Ammonia PET
Endothelial Dysfunction in Systemic Lupus Erythematosus: Evaluation with 13N-Ammonia PET
复制标题
DOI：
10.2967/jnumed.110.078212
复制
发表时间：
2010-12-01
影响因子：
9.3
通讯作者：
Posadas-Romero, Carlos
中科院分区：
文献类型：
--
作者：
Alexanderson, Erick;Ochoa, Juan M.;Posadas-Romero, Carlos
系统性红斑狼疮（SLE）影响多个器官和系统，严重累及心血管系统。本研究的目的是通过 N-13-氨 PET 评估无症状 SLE 患者是否存在内皮功能障碍。方法：我们招募了 16 名患有 SLE 的女性和 16 名健康女性。在休息时、冷加压试验 (CPT) 期间和应激期间，使用 64 层 PET/CT 扫描仪对心肌血流量 (MBF) 进行量化。计算内皮依赖性血管舒张指数、％Delta MBF 和心肌血流储备 (MFR)。结果：SLE 组有 16 名女性（平均年龄 +/- SD，31.4 +/- 8.3 岁），健康对照组有 16 名女性（31.5 +/- 11.1 岁）。 SLE 患者的平均内皮依赖性血管舒张指数和 %Delta MBF 显着较低（分别为 1.18 +/- 0.55 与 1.63 +/- 0.65，P = 0.04，以及 18 +/- 55 与 63 +/- 65，P = 0.04）。 SLE 组的 MFR 也较低（2.41 +/- 0.59 vs. 2.73 +/- 0.77，P = 0.20）。结论：无活动性疾病的 SLE 患者存在冠状动脉血流异常和内皮功能障碍。有必要制定和强化针对 SLE 患者 CAD 的治疗策略。
Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with N-13-ammonia PET in asymptomatic SLE patients. Methods: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %Delta MBF, and myocardial flow reserve (MFR) were calculated. Results: There were 16 women in the SLE group (mean age +/- SD, 31.4 +/- 8.3 y) and 16 women in the healthy control group (31.5 +/- 11.1 y). Mean endothelium-dependent vasodilatation index and %Delta MBF were significantly lower in SLE patients (1.18 +/- 0.55 vs. 1.63 +/- 0.65, P = 0.04, and 18 +/- 55 vs. 63 +/- 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 +/- 0.59 vs. 2.73 +/- 0.77, P = 0.20). Conclusion: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients.