Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry.
Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry.
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DOI：
10.1039/b706416k
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发表时间：
2007-11
影响因子：
11.9
通讯作者：
S. Wenzel;R. Müller
中科院分区：
文献类型：
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作者：
S. Wenzel;R. Müller
在过去的20年里，黏菌已经从高度外来的生物发展成为具有有趣生物活性的微生物天然产物的主要来源之一。最近对黏菌次级代谢的遗传学和生物化学的更好理解，揭示了多酮合成酶和非核糖体肽合成酶的许多特殊组合的参与，这些组合的操作远非教科书上的生物合成逻辑。在本重点，最近描述的系统的选定的例子进行了讨论，并与迄今为止已知的所有黏菌天然产品装配线进行了比较。
Over the last 20 years myxobacteria have made their way from highly exotic organisms to one of the major sources of microbial natural products with interesting biological activities. Recent progress towards achieving a better understanding of the genetics and the biochemistry of myxobacterial secondary metabolism, revealed the involvement of numerous exceptional combinations of polyketide synthases and nonribosomal peptide synthetases operating far from textbook biosynthetic logic. In this Highlight, selected examples of recently described systems are discussed in comparison to all myxobacterial natural product assembly lines known to date.