Activity of cat premotor cortex neurons during visually guided stepping
Activity of cat premotor cortex neurons during visually guided stepping
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DOI：
10.1152/jn.00114.2023
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发表时间：
2023-10-23
影响因子：
2.5
通讯作者：
Beloozerova，Irina N.
中科院分区：
文献类型：
--
作者：
Di Prisco，Gonzalo Viana;Marlinski，Vladimir;Beloozerova，Irina N.
视觉控制步骤在日常生活中至关重要。几个运动中心涉及在复杂的表面上的步骤的视觉控制，然而，参与一个大的皮质运动区，运动前皮质，在地上运动过程中的步骤的视觉指导还没有被检查。在这里，我们分析了猫运动前皮层6aα和6aγ区神经元的活动，因为猫在平坦的表面上行走，不需要视觉引导的步骤，并踩在水平放置的梯子的横梁上或越过障碍物，需要视觉控制的步骤。视觉依赖和视觉独立的步进之间的神经元放电的比较显示的组件的活动相关的视觉指导的步骤。我们发现，59%的神经元的放电活动与平坦表面上的步幅节奏调制，并且83-86%的群体的活动在过渡到梯子上或障碍物上的运动时发生变化。33-44%的神经元的放电频率和步幅相关活动调制的深度发生了变化，58-73%的神经元的步幅相位发生了变化。这些结果表明，6aα和6aγ区神经元的相当大的比例参与视觉引导的步骤。与初级运动皮层相比，细胞的比例，其放电活动的变化后，从视觉无关的过渡到视觉依赖的步进，是较低的和首选阶段的放电活动之间的任务更经常改变。新&值得注意的是，视觉控制的步骤是至关重要的日常生活，但是，它是如何实现的还没有很好的理解。在这里，我们分析了前运动皮层中的神经元如何响应复杂表面上视觉控制步骤的需求。我们的结论是，前运动皮层神经元参与皮层网络支持视觉控制的步骤，通过修改的相位，强度和显着性，他们的放电活动。
Visual control of steps is critical in everyday life. Several motor centers are implicated in visual control of steps on a complex surface, however, participation of a large cortical motor area, the premotor cortex, in visual guidance of steps during overground locomotion has not been examined. Here, we analyzed the activity of neurons in feline premotor cortex areas 6aα and 6aγ as cats walked on the flat surface where visual guidance of steps is not needed and stepped on crosspieces of a horizontally placed ladder or over barriers where visual control of steps is required. The comparison of neuronal firing between vision-dependent and vision-independent stepping revealed components of the activity related to visual guidance of steps. We found that the firing activity of 59% of neurons was modulated with the rhythm of strides on the flat surface, and the activity of 83–86% of the population changed upon transition to locomotion on the ladder or with barriers. The firing rate and the depth of the stride-related activity modulation of 33–44% of neurons changed, and the stride phases where neurons preferred to fire changed for 58–73% of neurons. These results indicate that a substantial proportion of areas 6aα and 6aγ neurons is involved in visual guidance of steps. Compared with the primary motor cortex, the proportion of cells, the firing activity of which changed upon transition from vision-independent to vision-dependent stepping, was lower and the preferred phases of the firing activity changed more often between the tasks.NEW & NOTEWORTHYVisual control of steps is critical for daily living, however, how it is achieved is not well understood. Here, we analyzed how neurons in the premotor cortex respond to the demand for visual control of steps on a complex surface. We conclude that premotor cortex neurons participate in the cortical network supporting visual control of steps by modifying the phase, intensity, and salience of their firing activity.