Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep
Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep
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DOI：
10.1016/s0002-9378(98)70518-6
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发表时间：
1998-05-01
影响因子：
9.8
通讯作者：
Ervin, MG
中科院分区：
文献类型：
--
作者：
Jobe, AH;Wada, N;Ervin, MG
目的：我们评估单次或三次重复剂量倍他米松对绵羊早产儿和足月分娩时胎儿生长的影响。研究设计：妊娠母羊在104日龄时随机接受1剂0.5 mg/kg倍他米松；在胎龄104、111和118天给予三剂倍他米松；或者生理盐水作为对照。羔羊在125天（早产）或145天（足月）胎龄时分娩，以评估胎儿生长情况。结果：孕104天单次倍他米松暴露导致对称生长迟缓，孕125天为11%，足月为14%。三剂量暴露使早产羔羊体重减少25%，足月羔羊体重减少19%。早产儿每公斤体重器官蛋白和脱氧核糖核酸有选择性地降低。在足月，器官重量、蛋白质和脱氧核糖核酸的减少与出生体重的减少成正比。结论：在妊娠早期给药1次或3次糖皮质激素可导致早产羔羊对称生长迟缓，胎儿尺寸减小持续至足月。
OBJECTIVE: We evaluated the effects of single or three repeated doses of maternal betamethasone on fetal growth at preterm and term delivery in sheep.STUDY DESIGN: Pregnant ewes were randomly assigned to receive one dose of 0.5 mg/kg betamethasone at 104 days' gestational age; three doses of betamethasone at 104, 111, and 118 days' gestational age; or saline for controls. Lambs were delivered at 125 days' (preterm) or at 145 days' (term) gestational age for assessments of fetal growth.RESULTS: The single betamethasone exposure at 104 days' gestational age caused symmetric growth retardation of 11% at 125 days' gestational age and 14% at term. The three-dose exposures decreased body weights by 25% in preterm lambs and by 19% at term. Organ protein and deoxyribonucleic acid per kilogram of body weight were selectively decreased in preterm lambs. At term the decreases in organ weight, protein, and deoxyribonucleic acid were proportionate to the decreased birth weight.CONCLUSION: One or three doses of maternal glucocorticoids begun at an early gestational age caused symmetric growth retardation in lambs delivered prematurely and the decreased fetal size persisted to term.