Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice.
Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice.
复制标题
小鼠类固醇硫酸酯酶 X 连锁的证据：XX 和 XO 小鼠卵母细胞中的类固醇硫酸酯酶水平。
DOI：
10.1093/genetics/103.1.137
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发表时间：
1983
期刊：
影响因子：
3.3
通讯作者：
Rivest,M
中科院分区：
文献类型：
--
作者：
Gartler,SM;Rivest,M
沿着乳酸脱氢酶（LDH）和葡萄糖-6-磷酸脱氢酶（G6 PD），测定XX和XO小鼠成熟卵母细胞中类固醇硫酸酯酶（STS）水平。XX和X卵母细胞的LDH水平相等，而XX卵母细胞的STS和G6 PD水平约为X卵母细胞的两倍。这些结果表明STS基因在小鼠中是X连锁的，就像在人类中一样。对XX和XO小鼠肾组织中STS的分析表明，该基因具有剂量补偿作用，这与在人类中观察到的结果不同。
The steroid sulfatase (STS) levels in mature oocytes ofXXandXOmice were assayed along with lactate dehydrogenase (LDH), an autosomal marker, and glucose-6-phosphate dehydrogenase (G6PD), a known X-linked gene. LDH levels inXXandXOoocytes were equal, whereas STS and G6PD levels were approximately twice as high inXXoocytes as inXOoocytes. These results indicate that the STS gene is X-linked in the mouse just as it is in humans. Assays of STS in kidney tissue ofXXandXOmice indicated dosage compensation for the gene, which is different from that observed in humans.