Concurrent measures of feeding and locomotion in rats.
Concurrent measures of feeding and locomotion in rats.
复制标题
大鼠进食和运动的同时测量。
DOI：
10.1016/j.physbeh.2005.03.006
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Davis,KristinaW
中科院分区：
文献类型：
--
作者：
Wellman,PaulJ;Ho,DaoH;Davis,KristinaW
包括安非他明和可卡因在内的精神兴奋剂会诱导运动和刻板行为，并抑制进食。对精神兴奋剂的生物行为作用的研究通常集中在运动上，很少集中在进食上，很少在同一动物中结合考虑这些措施。由于精神兴奋剂引起的多动可能与其他运动行为（包括进食）竞争，因此同时评估精神兴奋剂治疗后进食和运动的变化非常重要。本论文描述了一种修改的自动活动室，其中每分钟的记录的食物消耗收集在并行的评估运动。本实验通过表征通过给予低吞噬剂量的酒石酸烟碱（0.28 mg/kg（作为碱），IP）或盐酸可卡因（7.5 mg/kg，IP）产生的运动和进食的时间变化来说明该方法。在这些剂量下，尼古丁抑制进食和运动，而可卡因抑制进食，但促进向前运动。这些结果支持该装置的可行性和用于分离进食和运动的并行方法。
Psychostimulants including amphetamine and cocaine induce locomotion and stereotypy and suppress eating. Studies of the biobehavioral actions of psychostimulants commonly focus on locomotion and less commonly on feeding, and only rarely are these measures considered in conjunction within the same animal. Inasmuch as hyperactivity induced by a psychostimulant may compete with other motor behaviors, including eating, it would be important to concurrently assess changes in eating and locomotion after psychostimulant treatment. The present paper describes a modification of an automated activity chamber in which minute-by-minute recordings of food consumption are gathered in parallel with an assessment of locomotion. The present experiment illustrates the method by characterizing the temporal changes in locomotion and eating produced by administration of hypophagic doses of nicotine tartrate (0.28 mg/kg (as the base), IP) or cocaine hydrochloride (7.5 mg/kg, IP). At these doses, nicotine suppressed eating and locomotion, whereas cocaine suppressed eating, but facilitated forward locomotion. These outcomes support the viability of this apparatus and the concurrent method for the dissociation of feeding and locomotion.