Chromatographic enantioseparations of binaphthyl compounds on an immobilized polysaccharide-based chiral stationary phase.
Chromatographic enantioseparations of binaphthyl compounds on an immobilized polysaccharide-based chiral stationary phase.
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DOI：
10.1016/j.chroma.2008.09.048
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发表时间：
2008-11
期刊：
影响因子：
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通讯作者：
W.‐W. Weng;Hongxu Guo;F. Zhan;Hongli Fang;Qingxiang Wang;Bixia Yao;Shunxing Li
中科院分区：
文献类型：
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作者：
W.‐W. Weng;Hongxu Guo;F. Zhan;Hongli Fang;Qingxiang Wang;Bixia Yao;Shunxing Li
采用固定化多糖手性固定相Chiralpak IA对7种联萘类化合物进行了手性拆分。实验在正相条件下进行。考察了极性调节剂和柱温对保留时间和分离因子的影响。所有检测化合物均获得完全分离。这是迄今为止报道的唯一一种1，1 ′-联-2-萘酚及其单醚、二醚和双酯衍生物在固定相上均能实现对映体分离的方法。根据Van 't霍夫图推导了表观热力学参数，并对手性识别机理进行了讨论。
Seven binaphthyl compounds were enantioseparated by HPLC with an immobilized polysaccharide-based chiral stationary phase, Chiralpak IA. The experiments were performed under normal-phase conditions. Effects of polar modifier and column temperature on the retention time and separation factor were evaluated. All examined compounds obtained complete resolutions. This was the unique one ever reported that 1,1′-bi-2-naphthol and its monoether, diether and diester derivatives could all be enantioseparated on a given CSP. Apparent thermodynamic parameters were also deduced from Van’t Hoff plots, and some aspects of chiral recognition mechanism were discussed further.