The G-triplex DNA could function as a new variety of DNA peroxidase
The G-triplex DNA could function as a new variety of DNA peroxidase
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G-三链DNA可以作为一种新的DNA过氧化物酶
DOI：
10.1039/c3cc44075c
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Zhou, Xiang
中科院分区：
文献类型：
--
作者：
Wang, Shaoru;Fu, Boshi;Zhou, Xiang
本研究首次使用不同的DNA结合分析方法研究了氯化血红素与T1的G -三链体DNA的相互作用。使用T1可显著增强氯化血红素较低的固有过氧化物酶活性。此外，观察到具有一个关键鸟嘌呤突变的T2或T3的氧化增强作用大幅降低，并且观察到的T1的过氧化物酶活性应直接归因于与氯化血红素复合的G -三链体。
This study is the first to investigate the interactions of hemin with a G-triplex DNA of T1 using different DNA binding assays. The low intrinsic peroxidatic activity of hemin could be significantly enhanced using T1. Furthermore, much decreased oxidation enhancement by T2 or T3 with one key guanine mutation was observed, and the observed peroxidatic activity of T1 should be directly due to the G-triplex complexed with hemin.