Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease
Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease
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DOI：
10.1016/s0197-4580(99)00103-7
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发表时间：
2000-01-01
影响因子：
4.2
通讯作者：
Siest, G
中科院分区：
文献类型：
--
作者：
Merched, A;Xia, Y;Siest, G
对98例阿尔茨海默病（AD）患者（77.56 ± 8.83岁）和59例健康老年人（75.37 ± 5.27岁）的血清载脂蛋白（apo）AI浓度进行了研究。AD患者的ApoAI水平显著降低（p < 10（-7））。apoAI临界值为1.50 g/L时，区分两组的敏感性为71%，特异性为69%。ApoAI水平与患者的简易精神状态（MMSE）评分高度相关（p < 0.0001）。这些关系仍然显着调整后的多重测试。我们的研究结果提出了问题的潜在意义载脂蛋白AI在AD的发病机制，并提出血清载脂蛋白AI浓度作为一个重要的生化指标。(C)2000 Elsevier Science Inc. All rights reserved.
Serum apolipoprotein (apo) AI concentration was studied in 98 Alzheimer's disease (AD) patients (77.56 +/- 8.83 years) and 59 healthy, elderly controls (75.37 +/- 5.27 years). ApoAI levels were significantly lower (p < 10(-7)) in AD patients. An apoAI cutoff value of 1.50 g/L, could distinguish between the two groups with a sensitivity of 71% and a specificity of 69%. ApoAI levels were highly correlated with mini-mental state (MMSE) scores of patients (p < 0.0001). These relationships remained significant after adjustment for multiple testing. Our findings raise the question of the potential implication of apoAI in the etiopathology of AD and bring serum apoAI concentration to the fore as an important biochemical marker. (C) 2000 Elsevier Science Inc. All rights reserved.