Dry Eye and Quantitative and Qualitative Changes of Meibomian Glands in Patients With Pemphigus
Dry Eye and Quantitative and Qualitative Changes of Meibomian Glands in Patients With Pemphigus
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DOI：
10.1097/ico.0000000000002356
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发表时间：
2020-09-01
期刊：
影响因子：
2.8
通讯作者：
Yagci, Ayse
中科院分区：
文献类型：
--
作者：
Kiyat, Pelin;Palamar, Melis;Yagci, Ayse
目的：探讨天疱疮患者干眼及睑板腺的定量和定性变化。研究方法：选取天疱疮患者20例（组1）和健康志愿者20例（组2），每组20例。采用牛津量表评分、泪膜破裂时间、Schirmer 1试验和眼表疾病指数评分评估来评价干眼症。通过上眼睑和下眼睑睑痣照相术（SL-D 701; Topcon，艾塞尔，荷兰）评估睑板腺的形态变化和脱落率。对每个眼睑的睑板腺脱落率进行评分，从0级（无损失）到3级（损失面积>总睑板腺面积的2/3）。结果：第1组和第2组的平均年龄分别为51.8 ± 11.1岁（范围：32-73岁）和50.4 ± 9.6岁（范围：32-70岁）（P= 0.672）。组1的Schirmer 1和泪膜破裂时间低于组2，Oxford和眼表疾病指数高于组2，差异有统计学意义（分别为P= 0.01，P <0.001，P = 0.001和P < 0.001）。第1组的上眼睑、下眼睑和总眼睑睑缘评分值显著高于第2组（分别为P= 0.005，P = 0.018和P = 0.002）。第1组中16眼（80%）检测到睑板腺的形态学改变。结论：天疱疮患者与健康人的干眼试验结果和睑板腺形态学差异有统计学意义。天疱疮患者应监测干眼和睑板腺功能障碍，并及时治疗，以防止干眼的严重后果。
Purpose: To evaluate dry eye and quantitative and qualitative changes of meibomian glands with meibography in patients with pemphigus. Methods: Twenty left eyes of 20 patients with pemphigus (group 1) and 20 left eyes of 20 age- and sex-matched healthy volunteers (group 2) were enrolled. Dry eye was evaluated with Oxford scale scoring, tear film breakup time, Schirmer 1 tests, and Ocular Surface Disease Index score assessments. Morphological changes and dropout ratio of meibomian glands were evaluated by upper and lower eyelid meibography (SL-D701; Topcon, IJssel, The Netherlands). Meibomian gland dropout ratio was scored for each eyelid from grade 0 (no loss) through grade 3 (lost area >2/3 of the total meibomian gland area). Results: The mean ages of group 1 and group 2 were 51.8 +/- 11.1 (range: 32-73) and 50.4 +/- 9.6 years (range: 32-70), respectively (P= 0.672). Schirmer 1 and tear film breakup time values were lower and Oxford and Ocular Surface Disease Index scores were higher in group 1 when compared with group 2, and the differences were statistically significant (P= 0.01,P< 0.001,P= 0.001, andP< 0.001, respectively). Upper eyelid, lower eyelid, and total eyelid meiboscore values were significantly higher in group 1 (P= 0.005,P= 0.018, andP= 0.002, respectively). Morphological changes in meibomian glands were detected in 16 eyes (80%) among group 1. Conclusions: Between patients with pemphigus and those who were healthy, there were significant differences in the results of dry eye tests and meibomian gland morphology. Patients with pemphigus should be monitored for dry eye and meibomian gland dysfunction and be promptly treated to prevent the serious consequences of dry eye.