Strain amplification in the bone mechanosensory system
Strain amplification in the bone mechanosensory system
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DOI：
10.1097/00000441-199809000-00006
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发表时间：
1998-09-01
影响因子：
3.1
通讯作者：
Weinbaum, S
中科院分区：
文献类型：
--
作者：
Cowin, SC;Weinbaum, S
本文讨论了在骨细胞膜处诱导的应变可能从整个骨由于机械载荷而经历的应变放大的潜在机制。这些机制解决的问题是，这些机械载荷诱导的小应变（通常）约0.1%（但高达0.5%）施加于整个骨骼，如何在骨基质中埋在其陷窝中的骨细胞膜上放大到1%或更大的应变。这个问题的答案是骨机械感觉系统和体外细胞研究与体内细胞反应相关的一个重要环节。
This article discusses the potential mechanisms by which the strain induced at the membrane of an osteocyte may be amplified from the strain experienced by the whole bone due to mechanical loading. These mechanisms address the question of how these mechanical load-induced small strains of (typically) about 0.1% (but up to 0.5%) applied to a whole bone are amplified to strains of 1% or larger at the membrane of the osteocyte buried in its lacuna in the bone matrix. The answer to this question is an important link in the mechanosensory system in bone and in relating in vitro cell studies to in vivo cellular response.