Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients.
Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients.
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2019 年冠状病毒病 Messenger RNA 疫苗接种者对严重急性呼吸系统综合症冠状病毒 2 Omicron 变体的抗体和 T 细胞反应不一致。
DOI：
10.1093/cid/ciac305
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Blankson,JoelN
中科院分区：
文献类型：
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作者：
Woldemeskel,BezawitA;Garliss,CarolineC;Aytenfisu,TihitinaY;Johnston,TrevorS;Cox,AndreaL;Karaba,AndrewH;Blankson,JoelN
在15个mRNA疫苗受体中，我们比较了抗体和T细胞对SARS-CoV-2疫苗株刺突蛋白的反应与对Omicron变体的反应。虽然这些个体具有明显较低水平的抑制Omicron刺突蛋白与ACE2结合的抗体，但T细胞反应没有差异。
We compared antibody and T cell responses against the SARS-CoV-2 vaccine strain spike protein to responses against the Omicron variant in 15 mRNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T cell responses.