The genome of the natural genetic engineer Agrobacterium tumefaciens C58
The genome of the natural genetic engineer Agrobacterium tumefaciens C58
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DOI：
10.1126/science.1066804
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发表时间：
2001-12-14
期刊：
影响因子：
56.9
通讯作者：
Nester, EW
中科院分区：
文献类型：
--
作者：
Wood, DW;Setubal, JC;Nester, EW
植物病原菌根癌农杆菌C58的基因组全长5.67亿碱基，由一条环状染色体、一条线状染色体和两个质粒组成。根癌农杆菌基因组和植物共生体紫花苜蓿基因组之间广泛的同源性和核苷酸共线性表明了最近的进化分歧。它们的相似之处包括促进在竞争激烈的根际生存的代谢、运输和调节系统；它们在基因组结构和毒力基因互补方面的差异明显。根癌农杆菌序列的获得将有助于研究致病的分子基础以及致病和共生生活方式的进化差异。
The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.