Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment.
Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment.
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DOI：
10.4137/ehi.s39149
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发表时间：
2016
影响因子：
2.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Franklin G;Harari H;Ahsan S;Bello D;Sterling DA;Nedrelow J;Raynaud S;Biswas S;Liu Y
我们对残留异氰酸酯及其在新生儿中的潜在初始暴露进行了试点定性和定量评估，因为对其接触效应知之甚少。在新生儿重症监护病房 (NICU) 库房清点后，使用 Surface SWYPE™ 对聚氨酯 (PU) 和 PU 泡沫 (PUF) 设备和产品的残留异氰酸酯进行定性评估。使用 UPLC-UV-MS/MS 方法对含有异氰酸酯的样品进行亚甲基二苯基二异氰酸酯 (MDI) 物质的定量检测。测试的 37 种产品和设备中有 10 种表明表面存在游离和结合的残留异氰酸酯； PU/PUF 件含有芳香族异氰酸酯；一种产品含有脂肪族异氰酸酯。总体而言，量化的平均 MDI 浓度较低（4,4'-MDI = 0.52 至 140.1 pg/mg）和（2,4'-MDI = 0.01 至 4.48 pg/mg）。 4,4'-MDI 物质具有最高的测量浓度（280 pg/mg）。常用的医疗器械/产品含有低浓度但可测量的残留异氰酸酯。量化其他异氰酸酯种类以及新生儿皮肤从这些设备和产品中接触异氰酸酯的情况需要进一步研究。
We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4′-MDI = 0.52 to 140.1 pg/mg) and (2,4′-MDI = 0.01 to 4.48 pg/mg). The 4,4′-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.