TRPM2
TRPM2
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DOI：
10.1007/978-3-642-54215-2_16
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Penner, Reinhold
中科院分区：
文献类型：
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作者：
Faouzi, Malika;Penner, Reinhold
TRPM 2是瞬时受体电位美拉汀相关（TRPM）阳离子通道家族的第二个成员。该蛋白质广泛表达，包括在脑、免疫系统、内分泌细胞和内皮细胞中。它体现了离子通道功能和酶促ADP-核糖（ADPr）水解酶活性。TRPM 2是一种嵌入质膜和/或溶酶体区室中的Ca 2+渗透性非选择性阳离子通道，主要由细胞内ADP-核糖（ADPr）和Ca 2+以协同方式激活。它也被活性氧和氮物质（ROS/NOS）激活，并被其他因子（如环状ADPr和NAADP）增强，同时被渗透质子（酸性pH）和腺苷一磷酸（AMP）抑制。TRPM 2的激活导致细胞内Ca 2+水平的增加，其可以通过释放囊泡介质（例如，细胞因子、神经递质、胰岛素），并且在极端情况下可在氧化应激下诱导凋亡和坏死细胞死亡。
TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM) family of cation channels. The protein is widely expressed including in the brain, immune system, endocrine cells, and endothelia. It embodies both ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity. TRPM2 is a Ca2+-permeable nonselective cation channel embedded in the plasma membrane and/or lysosomal compartments that is primarily activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca2+. It is also activated by reactive oxygen and nitrogen species (ROS/NOS) and enhanced by additional factors, such as cyclic ADPr and NAADP, while inhibited by permeating protons (acidic pH) and adenosine monophosphate (AMP). Activation of TRPM2 leads to increases in intracellular Ca2+ levels, which can serve signaling roles in inflammatory and secretory cells through release of vesicular mediators (e.g., cytokines, neurotransmitters, insulin) and in extreme cases can induce apoptotic and necrotic cell death under oxidative stress.