Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001
Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001
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DOI：
10.1378/chest.128.4.2005
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发表时间：
2005-10-01
期刊：
影响因子：
9.6
通讯作者：
Mannino, DA
中科院分区：
文献类型：
--
作者：
Holguin, F;Folch, E;Mannino, DA
研究目的：慢性阻塞性肺病是美国死亡率和发病率的主要原因之一，但对慢性阻塞性肺病住院患者的合并症和死亡率的患病率知之甚少。设计：从1979年至2001年的全国医院出院调查中，我们评估了25岁成人COPD是否与几种合并症的患病率和住院死亡率增加有关。结果：1979年至2001年期间，估计共有47,404,700名COPD患者出院（占所有25岁以下成人住院人数的8.5%）；37,540,374例（79.2%）以COPD为次要诊断，9,864,278例（20.8%）以COPD为主要诊断。肺炎、充血性心力衰竭、缺血性心脏病、胸部恶性肿瘤和呼吸衰竭的患病率和住院死亡率在任何提及COPD的出院患者中都更高。结论：在全国代表性的住院样本中，在出院诊断中提及COPD与较高的住院患病率和其他合并症的住院死亡率相关。这些结果强调了与COPD相关的疾病负担可能被低估的事实。
Study objectives: COPD is one of the leading causes of mortality and morbidity in the United States, yet little is known about the prevalence of comorbid conditions and mortality in hospitalized patients with COPD.Design: From the National Hospital Discharge Survey,, 1979 to 2001, we evaluated whether or not COPD in adults >= 25 years old is associated with increased prevalence and in-hospital mortality of several comorbidities.Results: During 1979 to 2001, there were an estimated total of 47,404,700 hospital discharges (8.5% of all hospitalizations in adults > 25 years old) of patients with COPD; 37,540,374 discharges (79.2%) were made with COPD as a secondary diagnosis, and 9,864,278 discharges (20.8%) were made with COPD as the primary diagnosis. The prevalence and in-hospital mortality for pneumonia, congestive heart failure, ischemic heart disease, thoracic malignancies, and respiratory failure were larger in hospital discharges with any mention of COPD.Conclusions: In a nationally, representative sample of hospitalizations, any, mention of COPD in the discharge diagnosis is associated with higher hospitalization prevalence and in-hospital mortality from other comorbidities. These results highlight the fact that the burden of disease associated with COPD is likely underestimated.