EVIDENCE FOR DOPAMINE D-2 RECEPTORS ON CHOLINERGIC INTERNEURONS IN THE RAT CAUDATE-PUTAMEN
EVIDENCE FOR DOPAMINE D-2 RECEPTORS ON CHOLINERGIC INTERNEURONS IN THE RAT CAUDATE-PUTAMEN
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DOI：
10.1016/0024-3205(88)90492-4
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
WAMSLEY, JK
中科院分区：
文献类型：
--
作者：
DAWSON, VL;DAWSON, TM;WAMSLEY, JK
乙基胆碱的氮丙啶离子（AF 64 A）是一种神经毒素，已证明对胆碱能神经元具有选择性。将AF 64 A单侧立体定位注射到大鼠的尾壳核中，导致多巴胺D-2受体的α 3减少，这通过[3 H]-舒必利结合的减少来证明。[3 H]-SCH 23390标记的多巴胺D-1受体未发生变化。通过用[3 H]-hemicholinium-3标记的Na+依赖性高亲和力胆碱摄取位点的减少来证明病变的功效。这些数据表明，一个人口的D-2受体突触后胆碱能中间神经元内纹状体的大鼠大脑。
The aziridinium ion of ethylcholine (AF64A) is a neurotoxin that has demonstrated selectivity for cholinergic neurons. Unilateral stereotaxic injection of AF64A into the caudate-putamen of rats, resulted in a3 decrease in dopamine D-2 receptors as evidenced by a decrease in [3H]-sulpiride binding. Dopamine D-1 receptors, labeled with [3H]-SCH 23390, were unchanged. The efficacy of the lesion was demonstrated by the reduction of Na+-dependent high affinity choline uptake sites labeled with [3H]-hemicholinium-3. These data indicate that a population of D-2 receptors are postsynaptic on cholinergic interneurons within the striatum of rat brain.