Incorporation of an antibacterial and radiopaque monomer in to dental resin system
Incorporation of an antibacterial and radiopaque monomer in to dental resin system
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DOI：
10.1016/j.dental.2012.04.026
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发表时间：
2012-08-01
期刊：
影响因子：
5
通讯作者：
Vallittu, Pekka K.
中科院分区：
文献类型：
--
作者：
He, Jingwei;Soderling, Eva;Vallittu, Pekka K.
目标。本研究的目的是在Bis-GMA/TEGDMA(50/50，wt/wt)牙科树脂体系中加入一种含碘的可聚合季铵盐化合物，制备抗菌不透射线牙科树脂，并对其单体转化率、力学性能、辐射不透性和抗菌效果进行评价。以CQ(0.7wt.%)和DMAEMA(0.7wt.%)为光引发体系，在Bis-GMA/TEGDMA(50/50，wt/wt)体系中加入3%和5%的2-二甲基-2-十二烷基-1-甲基丙烯氧基乙基碘铵(DDMAI)。通过FT-IR分析确定了单体转化率(DC)。用三点弯曲装置测量了聚合物的弯曲强度(FS)和弯曲弹性模量(Fm)。以铝阶梯形楔形板(0.5~4 mm)为校准标准，拍摄X线片以确定聚合物的不透射率。以变形链球菌为实验生物，采用单物种生物膜模型评价了聚合物的抗菌性能。所有试验均以不含DDMAI的BIS-GMA/TEGDMA为对照。方差分析显示，加入和不加入DDMAI的聚合物的DC差异无统计学意义(p>；0.05)。含3wt.%DDMAI的聚合物的FS高于对照材料(p<；0.05)，而含5wt.%DDMAI的聚合物的FS与对照材料相当(p>；0.05)。对照材料的平均Fm低于含3wt.%DDMAI的聚合物，高于含5wt.%DDMAI的聚合物，但差异不显著。随着DDMAI用量的增加，聚合物的辐射不透过率增加。在三种制剂中，含5wt.%DDMAI的聚合物抑制了临床相关年轻生物膜的形成。在树脂体系中加入DDMAI可以使其具有不透射线和抗菌性能，并且这两个性能似乎随着DDMAI用量的增加而提高。(C)2012年牙科材料学会。爱思唯尔有限公司出版。保留所有权利。
Objectives. The purpose of this study was to prepare antibacterial and radiopaque dental resin through adding one polymerizable quaternary ammonium compound with iodine as counter anion into Bis-GMA/TEGDMA (50/50, wt/wt) dental resin system, and evaluate the degree of monomer conversion, mechanical properties, radiopacity, and antibacterial effectiveness of the polymer.Methods. 2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) (3 wt.% and 5 wt.%) was added into a Bis-GMA/TEGDMA (50/50, wt/wt) resin system with CQ (0.7 wt.%) and DMAEMA (0.7 wt.%) as photoinitiation system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and flexural modulus (FM) of the polymer were measured using a three-point bending set up. Radiographs were taken to determine the radiopacity of the polymer, and aluminum step-wedge (0.5-4 mm) was used as calibration standard. A single-species biofilm model with Streptococcus mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA without DDMAI was used as control material in all of the tests.Results. ANOVA analysis revealed that there was no significant difference in DC between polymer with and without DDMAI (p > 0.05). Polymer with 3 wt.% DDMAI had higher FS than the control material (p < 0.05), while polymer with 5 wt.% DDMAI had comparable FS with the control material (p > 0.05). Though average FM of control material was lower than that of 3 wt.% DDMAI containing polymer and higher than 5 wt.% DDMAI containing polymer, but the differences were statistically insignificant. By increasing the quantity of DDMAI, the radiopacity of the polymer increased. Of the three formulations, the polymer with 5 wt.% DDMAI inhibited biofilm the formation of the clinically relevant young biofilm.Significance. Incorporation of DDMAI into resin system could endow it with radiopacity and antibacterial effectiveness, and these two properties seem to be improved with increasing the quantities of DDMAI. (C) 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.