Specificity of signaling from MAPKs to MAPKAPKs:: Kinases' Tango Nuevo
Specificity of signaling from MAPKs to MAPKAPKs:: Kinases' Tango Nuevo
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DOI：
10.2741/3136
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发表时间：
2008-05-01
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影响因子：
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通讯作者：
Gaestel, Matthias
中科院分区：
文献类型：
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作者：
Gaestel, Matthias
在哺乳动物细胞的信号网络中，MAPK激活的蛋白激酶(MAPKAPK)下游有多种MAPKs，如经典的MAPKs、ERK1/2、应激激活的p38MAPKs和非典型的MAPKs ERK3/4/5。本文就MAPK对MAPKAPK信号转导的特异性、蛋白-蛋白-相互作用的基本机制以及对亚细胞定位的影响等方面的研究进展作一综述。已经证明，这一信号部分的特异性是通过蛋白质结构域相互作用和受调控的亚细胞定位来维持的。这些机制使特定的MAPK通路能够通过特定的MAPKAPK独立发挥作用，但也允许不同的MAPK通路以协调的方式在下游信号转导中合作。
Within the signalling network of mammalian cells, MAPK-activated protein kinases (MAPKAPKs) have been identified downstream to various MAPKs, such as the classical MAPKs, ERK1/2, the stress-activated p38 MAPKs and the atypical MAPKs ERK3/4/5. Here, the current understanding of the specificity of MAPK to MAPKAPK signalling, the underlying mechanisms of protein-protein-interaction and the effects on subcellular localisation are reviewed. It is demonstrated that specificity in this signalling section is maintained by protein domain interactions and by regulated subcellular localisation. These mechanisms enable specific MAPK pathways to act independently via specific MAPKAPKs but also allow different MAPK pathways to cooperate in downstream signalling in a coordinated fashion.