Sex differences in platelet reactivity and response to low-dose aspirin therapy
Sex differences in platelet reactivity and response to low-dose aspirin therapy
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DOI：
10.1001/jama.295.12.1420
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发表时间：
2006-03-22
影响因子：
120.7
通讯作者：
Faraday, N
中科院分区：
文献类型：
--
作者：
Becker, DM;Segal, J;Faraday, N
最近的随机试验表明，女性可能不会从低剂量阿司匹林治疗中获得与男性相同的心脏保护益处。失败的阿司匹林抑制血小板聚集在women is one hypothesized mechanism.Objective To examine differential platelet reactivity to low-dose aspirin therapy by sexy.Design，Setting，and Participants A clinical trial of aspirin at 81 mg/d for 14 days was carried out in 571 men and 711 women.基线和阿司匹林治疗后的措施包括血小板聚集花生四烯酸，腺苷二磷酸，肾上腺素，血小板功能分析仪关闭time.Main结果测量性别差异环氧合酶1（考克斯-1）直接和间接血小板活化途径之前和之后的administrationofaspirin.Results在10的12血小板激动剂的曝光，妇女的血小板在基线时显着更具反应性。然而，在阿司匹林治疗后，女性的花生四烯酸聚集百分比（直接考克斯-1途径）比男性下降更多（P
Context Recent randomized trials suggest that women may not accrue the same cardioprotective benefits as men do from low-dose aspirin therapy used in primary prevention. Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism.Objective To examine differential platelet reactivity to low-dose aspirin therapy by sex.Design, Setting, and Participants A clinical trial of aspirin at 81 mg/d for 14 days was conducted in 571 men and 711 women. Baseline and post - aspirin therapy measures included platelet aggregation to arachidonic acid, adenosine diphosphate, epinephrine, and platelet function analyzer closure time.Main Outcome Measure Sex differences in cyclooxygenase 1 (COX-1) direct and indirect platelet activation pathways before and after administration of aspirin.Results In 10 of the 12 platelet agonist exposures, women's platelets were significantly more reactive at baseline. However, after aspirin therapy, the percent aggregation to arachidonic acid ( the direct COX-1 pathway) decreased more in women than in men ( P